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January 24, 2000Archives of Internal Medicine

Systematic Lung Scans Reveal a High Frequency of Silent Pulmonary Embolism in Patients With Proximal Deep Venous Thrombosis

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Why the study?

What is the frequency of silent pulmonary embolism detected by systematic lung scans in outpatients with proximal deep venous thrombosis?

Population

622 outpatients with proximal deep venous thrombosis confirmed by venography and no clinical indication of…

Design

Cohort

Follow-up

3 months

Authors

MMMichel MeignanUniversité Paris CitéJRJean RossoOspedale dell' AngeloHGHélène GauthierUniversité Paris Cité

Discussion

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Overview

May not justify routine baseline lung scans for recurrence prediction in proximal DVT outpatients; leaves open prospective trials on screening utility.

Structured PICO

What is the frequency of silent pulmonary embolism detected by systematic lung scans in outpatients with proximal deep venous thrombosis?

P
Population
622 outpatients with proximal deep venous thrombosis (DVT) confirmed by venography and no clinical indication of pulmonary embolism (PE)
I
Intervention
Systematic perfusion and ventilation lung scans
O
Outcome
Frequency of silent pulmonary embolism (high-probability scans)surrogate

Silent pulmonary embolism is highly prevalent (40-50%) in outpatients with proximal DVT, but baseline lung scans do not predict early thromboembolic recurrence during therapy.

Cite This Study

Meignan et al. (2000) studied this question.

synapsesocial.com/papers/6a7d40a37786afdcaca00aebhttps://doi.org/10.1001/archinte.160.2.159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Value of the Ventilation/Perfusion Scan in Acute Pulmonary Embolism1990 · 2,742 citations
  2. 2Randomized trial of subcutaneous low-molecular-weight heparin CY 216 (Fraxiparine) compared with intravenous unfractionated heparin in the curative treatment of submassive pulmonary embolism. A dose-ranging study.1992 · 90 citations
  3. 3A Comparison of Low-Molecular-Weight Heparin with Unfractionated Heparin for Acute Pulmonary Embolism1997 · 785 citations
  4. 4Chronic Thrombotic Obstruction of Major Pulmonary Arteries1983 · 116 citations
  5. 5Frequent Asymptomatic Pulmonary Embolism in Patients With Deep Venous Thrombosis1994 · 390 citations