Why the study?
Does lansoprazole prevent the development of gastric or duodenal ulcers in patients with a history of ulcers requiring long-term low-dose aspirin?
Population
461 Japanese patients with a history of gastric or duodenal ulcers who required long-term low-dose aspirin…
Comparison
Lansoprazole 15 mg once daily for 12 months or… vs Gefarnate 50 mg twice daily for 12 months or…
Design
RCT, randomized, double-blind, double-dummy
Follow-up
12 months or longer
Authors
Loading...
Supports lansoprazole for secondary ulcer prevention in long-term low-dose aspirin users; confirms marked risk reduction versus gefarnate in RCT.
Does lansoprazole prevent the development of gastric or duodenal ulcers in patients with a history of ulcers requiring long-term low-dose aspirin?
Lansoprazole 15 mg daily is highly effective for the secondary prevention of gastric or duodenal ulcers in patients requiring long-term low-dose aspirin therapy.
Sugano et al. (2011) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: