Why the study?
Does pantoprazole reduce the antiplatelet effectiveness of clopidogrel in patients after coronary stenting?
Population
336 patients evaluated 48 hours after percutaneous coronary stent implantation, treated with a loading dose…
Comparison
Pantoprazole comedication added to dual… vs No proton pump inhibitor comedication or…
Design
Cohort
Follow-up
48 hours
Authors
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No increased clopidogrel low-response seen with pantoprazole post-stenting; leaves open optimal PPI choice in observational cohorts.
Does pantoprazole reduce the antiplatelet effectiveness of clopidogrel in patients after coronary stenting?
Pantoprazole does not diminish the antiplatelet effectiveness of clopidogrel early after coronary stenting, suggesting it is a preferable PPI when comedication is needed.
Neubauer et al. (2010) studied this question.
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