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September 6, 2024HereditasOpen Access

Exploring the molecular mechanism of ginseng against anthracycline-induced cardiotoxicity based on network pharmacology, molecular docking and molecular dynamics simulation

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Design

Network pharmacology, molecular docking, CETSA, and molecular dynamics simulation study

Authors

LXLin XieSun Yat-sen UniversityHLHanze LiuChina Animal Health and Epidemiology CenterKZKe ZhangShihezi University

Discussion

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Implication

Does not support ginseng for AIC prevention; leaves open mechanistic targets for prospective validation.

Structured PICO

P
Population
Computational models and cellular thermal shift assay (CETSA) for anthracycline-induced cardiotoxicity
I
Intervention
Ginseng and its derived effector compounds (beta-Sitosterol, Kaempferol, and Fumarine)
O
Outcome
Molecular targets and pathways of ginseng against anthracycline-induced cardiotoxicitysurrogate

Network pharmacology and molecular simulations suggest ginseng's cardioprotective effects against anthracycline toxicity are mediated by compounds like Kaempferol targeting STAT1, CCNA2, and ICAM1.

Cite This Study

Xie et al. (2024) studied this question.

synapsesocial.com/papers/6a7d414c1e40f44868965beahttps://doi.org/10.1186/s41065-024-00334-y
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Also Consider

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  1. 1Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice2018 · 134 citations
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  3. 3Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload–Induced Heart Failure2016 · 143 citations
  4. 4Inhibitory effects of Panax ginseng glycoproteins in models of doxorubicin-induced cardiac toxicity in vivo and in vitro2021 · 16 citations
  5. 5β‐Sitosterol Enhances Cellular Glutathione Redox Cycling by Reactive Oxygen Species Generated From Mitochondrial Respiration: Protection Against Oxidant Injury in H9c2 Cells and Rat Hearts2013 · 62 citations