January 1, 2021Food & Function

Inhibitory effects of Panax ginseng glycoproteins in models of doxorubicin-induced cardiac toxicity in vivo and in vitro

View Full Paper

Ask AI

Bookmark

Key result

Panax ginseng glycoproteins alleviate doxorubicin-induced cardiotoxicity in vitro and in vivo by inhibiting apoptosis.

Population

In vitro (H9C2 cells) and in vivo models of DOX-induced cardiotoxicity

Comparison

PGP treatment in DOX-induced cardiotoxicity

Design

Preclinical in vitro and in vivo study

Authors

YCYajun Chen LWLei Wang TLTianjia Liu

Discussion

Member takes

Overview

Hypothesis-generating in animal models; does not support clinical adoption of ginseng glycoproteins for doxorubicin cardiotoxicity.

Structured PICO

Population

In vitro (H9C2 cells) and in vivo models of doxorubicin-induced cardiac toxicity

Intervention

Panax ginseng glycoproteins (PGP)

Outcome

Doxorubicin-induced cardiotoxicity (cell viability, apoptosis, myocardial oxidative stress)surrogate

Panax ginseng glycoproteins show potential in mitigating doxorubicin-induced cardiotoxicity in preclinical models.

Cite This Study

Chen et al. (2021) studied this question. Panax ginseng glycoproteins alleviated doxorubicin-induced cardiotoxicity by increasing cell viability and inhibiting apoptosis in vitro and in vivo.

synapsesocial.com/papers/6aa1fdfe1638f9f59880cdbf https://doi.org/10.1039/d1fo01307f

View Full Paper

Ask AI

Bookmark

January 1, 2021Food & Function

Inhibitory effects of Panax ginseng glycoproteins in models of doxorubicin-induced cardiac toxicity in vivo and in vitro

View Full Paper

Ask AI

Bookmark

Key result

Panax ginseng glycoproteins alleviate doxorubicin-induced cardiotoxicity in vitro and in vivo by inhibiting apoptosis.

Population

In vitro (H9C2 cells) and in vivo models of DOX-induced cardiotoxicity

Comparison

PGP treatment in DOX-induced cardiotoxicity

Design

Preclinical in vitro and in vivo study

Authors

YCYajun Chen LWLei Wang TLTianjia Liu

Discussion

Member takes

Overview

Hypothesis-generating in animal models; does not support clinical adoption of ginseng glycoproteins for doxorubicin cardiotoxicity.

Structured PICO

Population

In vitro (H9C2 cells) and in vivo models of doxorubicin-induced cardiac toxicity

Intervention

Panax ginseng glycoproteins (PGP)

Outcome

Doxorubicin-induced cardiotoxicity (cell viability, apoptosis, myocardial oxidative stress)surrogate

Panax ginseng glycoproteins show potential in mitigating doxorubicin-induced cardiotoxicity in preclinical models.

Cite This Study

Chen et al. (2021) studied this question. Panax ginseng glycoproteins alleviated doxorubicin-induced cardiotoxicity by increasing cell viability and inhibiting apoptosis in vitro and in vivo.

synapsesocial.com/papers/6aa1fdfe1638f9f59880cdbf https://doi.org/10.1039/d1fo01307f

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark