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October 21, 2022Research Journal of Pharmacy and TechnologyOpen Access

Panax ginseng as Antioxidant and Anti-inflammatory to reduce the Cardiotoxicity of Doxorubicin on rat module

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Key result

No clinical data is available as the provided text contains only author instructions for a journal.

Why the study?

Panax ginseng has antioxidant properties and may reduce chemotherapy side effects, but its effect on reducing doxorubicin-induced cardiotoxicity and cancer-modulating biomarkers required evaluation.

Does Panax ginseng reduce doxorubicin-induced cardiotoxicity in a rat model?

Comparison

Purified water vs Panax ginseng (100mg/kg) vs Panax ginseng with doxorubicin vs high-dose Panax ginseng

Design

Animal study with four groups

Authors

HAHany Akeel Al-HussaniyZMZainab N. MohammedAAAli Hikmat Alburghaif

Discussion

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Member takes

Overview

No clinical data available from this source; leaves open whether Panax ginseng reduces doxorubicin cardiotoxicity in humans.

Structured PICO

Does Panax ginseng reduce doxorubicin-induced cardiotoxicity in a rat model?

P
Population
40 rats (rat model)
I
Intervention
Panax ginseng orally (100 mg/kg or high dose) with or without doxorubicin
C
Comparator
Purified water (control) or doxorubicin alone
O
Outcome
Serum levels of cardiac biomarkers (cTnI, BNP), oxidative stress markers (LPO, MDA, GSH), inflammatory (TNF-α), and apoptotic (caspase-3) biomarkerssurrogate

In a rat model, Panax ginseng demonstrated cardioprotective effects against doxorubicin-induced cardiotoxicity by reducing oxidative stress and inflammation.

Cite This Study

Al-Hussaniy et al. (2022) studied this question. No clinical data is available as the provided text contains only author instructions for a journal.

synapsesocial.com/papers/6a98159c824c98cfb78bfba1https://doi.org/10.52711/0974-360x.2022.00771
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways2022 · 15 citations
  2. 2Protective Effect of Saponins from Panax notoginseng against Doxorubicin-Induced Cardiotoxicity in Mice2008 · 33 citations
  3. 3Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: A randomized, double-blind, placebo-controlled clinical trial2022 · 20 citations
  4. 4Inhibitory effects of Panax ginseng glycoproteins in models of doxorubicin-induced cardiac toxicity in vivo and in vitro2021 · 16 citations
  5. 5Panax ginseng reduces adriamycin-induced heart failure in rats2005 · 34 citations