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February 1, 2008Planta Medica

Pretreatment with Panax notoginseng saponins significantly protected mice from doxorubicin-induced cardiotoxicity by improving ventricular contractile function and lowering serum cardiac injury markers.

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Key result

Pretreatment with Panax notoginseng saponins significantly protected mice from doxorubicin-induced cardiotoxicity by improving ventricular contractile function and lowering serum cardiac injury markers.

Authors

LLLi LiuRSRun ShiQSQiang Shi

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Overview

Should not change doxorubicin regimens in patients; leaves open saponin cardioprotection for prospective clinical trials.

PICO

P
Population
ICR mice treated with doxorubicin to induce cardiotoxicity, evaluated after 72 hours of treatment.
I
Intervention / Comparator
Panax notoginseng saponins (PNS) vs Doxorubicin alone (20 mg/kg i.p.) (100 mg/kg i.g. for 5 consecutive days)
O
Primary Outcome
Cardiac function, serum levels of LDH, CK, CK-MB, and antioxidant enzymes

Cite This Study

Liu et al. (2008) studied Doxorubicin-induced cardiotoxicity. Panax notoginseng saponins (PNS) vs. Doxorubicin alone (20 mg/kg i.p.) was evaluated on Cardiac function, serum levels of LDH, CK, CK-MB, and antioxidant enzymes. Pretreatment with Panax notoginseng saponins significantly protected mice from doxorubicin-induced cardiotoxicity by improving ventricular contractile function and lowering serum cardiac injury markers.

synapsesocial.com/papers/6a97c0ed44220fce7874bb47https://doi.org/10.1055/s-2008-1034303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways2022 · 15 citations
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  3. 3Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats2022 · 50 citations
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  5. 5Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced CardiotoxicityIn VitroandIn Vivo2012 · 61 citations