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June 22, 2022Frontiers in PharmacologyOpen Access

Combination of Panax ginseng C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats

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Why the study?

The clinical use of doxorubicin is restricted by cumulative, dose-dependent cardiotoxicity, prompting the evaluation of cardioprotective strategies.

Does the combination of Panax ginseng and febuxostat prevent doxorubicin-induced acute cardiotoxicity in rats?

Population

Thirty-five Sprague Dawley male rats

Comparison

P. ginseng, febuxostat, and their combination vs DOX only and normal saline control

Design

Randomized preclinical animal study

Authors

HAHayder M. Al‐kuraishyHAHany Akeel Al-HussaniyAAAli I. Al‐Gareeb

Discussion

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Overview

May attenuate doxorubicin cardiotoxicity in rats; leaves open human translation and trials.

Structured PICO

Does the combination of Panax ginseng and febuxostat prevent doxorubicin-induced acute cardiotoxicity in rats?

P
Population
35 Sprague Dawley male rats (body weight 150-250 g)
I
Intervention
Combination of Panax ginseng (100 mg/kg oral) and febuxostat (10 mg/kg oral) daily for 10 days, with a single dose of doxorubicin (15 mg/kg IP) on day 8
C
Comparator
Normal saline (control), doxorubicin alone, doxorubicin + Panax ginseng alone, and doxorubicin + febuxostat alone
O
Outcome
Biomarkers of acute cardiac toxicity (GP, LPO, MDA, cTnI, BNP, caspase-3, TNF-α) and histopathological changes at day 11surrogate

The combination of Panax ginseng and febuxostat significantly attenuated doxorubicin-induced acute cardiotoxicity in rats through antioxidant and anti-inflammatory mechanisms.

Cite This Study

Al‐kuraishy et al. (2022) studied this question.

synapsesocial.com/papers/6a89d4b3abe412682d930624https://doi.org/10.3389/fphar.2022.905828
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Use of Panax Ginseng to Reduce the Cardiotoxicity of Doxorubicin and Study its Effect on Modulating Oxidative Stress, Inflammatory, and Apoptosis Pathways2022 · 15 citations
  2. 2Panax ginseng as Antioxidant and Anti-inflammatory to reduce the Cardiotoxicity of Doxorubicin on rat module2022 · 36 citations
  3. 3Protective Effect of Saponins from Panax notoginseng against Doxorubicin-Induced Cardiotoxicity in Mice2008 · 33 citations
  4. 4FEBUXOSTAT MODULATES OXIDATIVE AND APOPTOTIC PATHWAYS IN ACUTE DOXORUBICIN‑INDUCED CARDIOTOXICITY: AN EXPERIMENTAL ANIMAL MODEL STUDY2019 · 22 citations
  5. 5Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats2011 · 26 citations