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January 1, 2011Pharmacognosy ResearchOpen Access

Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats

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Key result

Prior administration of p-coumaric acid and naringenin ameliorated doxorubicin-induced biochemical alterations, including MDA, SOD, CAT, and GSH levels, in male rats.

Why the study?

Does the combination of p-coumaric acid and naringenin prevent doxorubicin-induced cardiotoxicity in male Swiss albino rats?

Population

Male Swiss albino rats (9 groups)

Comparison

Combination of p-coumaric acid and naringenin… vs Vehicle control, disease control, p-coumaric…

Design

Preclinical

Follow-up

30 days

Authors

SSShrutiS ShiromwarVCVijay R. Chidrawar

Discussion

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Overview

Should not change doxorubicin regimens; hypothesis-generating for flavonoid cardioprotection in anthracycline models.

Structured PICO

Does the combination of p-coumaric acid and naringenin prevent doxorubicin-induced cardiotoxicity in male Swiss albino rats?

P
Population
Male Swiss albino rats subjected to doxorubicin-induced cardiotoxicity.
I
Intervention
Combination of p-coumaric acid (PC) and naringenin (NR) administered orally for 30 days prior to doxorubicin challenge
C
Comparator
Vehicle control (saline), disease control (doxorubicin 15 mg/kg i.p. alone), p-coumaric acid alone, naringenin alone, and Vitamin E (100 mg/kg/day)
O
Outcome
Biochemical alterations characteristic of cardiac toxicity (MDA, SOD, CAT, and GSH levels)surrogate

The combination of p-coumaric acid and naringenin protects against doxorubicin-induced cardiotoxicity in a rat model by ameliorating oxidative stress markers.

Cite This Study

Shiromwar et al. (2011) studied Doxorubicin-induced cardiotoxicity. Combination of p-coumaric acid (PC) and naringenin (NR) vs. Doxorubicin alone (disease control) and vehicle control was evaluated on Biochemical markers of cardiac toxicity (MDA, SOD, CAT, and GSH levels). Prior administration of p-coumaric acid and naringenin ameliorated doxorubicin-induced biochemical alterations, including MDA, SOD, CAT, and GSH levels, in male rats.

synapsesocial.com/papers/6a8b1d91c12eaf65c8b1fa36https://doi.org/10.4103/0974-8490.85012
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