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February 19, 2019Asian Journal of Pharmaceutical and Clinical ResearchOpen Access

Febuxostat Modulates Oxidative and Apoptotic Pathways in Acute Doxorubicin‑induced Cardiotoxicity: An Experimental Animal Model Study

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Why the study?

Doxorubicin use is limited by toxicity to normal cells, including complex cardiotoxicity involving free radical formation, prompting investigation into whether febuxostat modulates oxidative stress and apoptosis in acute cardiotoxicity.

Does febuxostat reduce doxorubicin-induced acute cardiotoxicity in Sprague Dawley male rats?

Population

30 Sprague Dawley male rats

Comparison

Febuxostat plus doxorubicin vs normal saline plus doxorubicin vs normal saline alone

Design

Experimental animal model study

Follow-up

10 days

Authors

HAHayder M. Al‐kuraishyMustansiriyah UniversityAAAli I. Al‐GareebMustansiriyah UniversityHAHany Akeel Al-HussaniyUniversity of Baghdad

Discussion

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Overview

Hypothesis-generating in rats; clinical trials required before considering febuxostat with doxorubicin.

Structured PICO

Does febuxostat reduce doxorubicin-induced acute cardiotoxicity in Sprague Dawley male rats?

P
Population
30 Sprague Dawley male rats
I
Intervention
Febuxostat (10 mg/kg, po) for 10 successive days plus single dose of doxorubicin (15 mg/kg, I.P.)
C
Comparator
Normal saline plus single dose of doxorubicin (15 mg/kg, IP) (positive control) and normal saline alone (negative control)
O
Outcome
Serum brain natriuretic peptide (BNP), cardiac troponin I (cTn-I), caspase-3, glutathione peroxidase (GSH-Px), lipid peroxidase (LPO), malondialdehyde (MDA), and tumor necrosis factor alphasurrogate

In a rat model, febuxostat attenuated doxorubicin-induced cardiotoxicity by modulating antioxidant and antiapoptotic biomarkers.

Cite This Study

Al‐kuraishy et al. (2019) studied this question.

synapsesocial.com/papers/6a86aa513d239a2773cf79c9https://doi.org/10.22159/ajpcr.2019.v12i4.31162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats2011 · 41 citations
  2. 2Comparison of Cardiac Troponin I and T, Including the Evaluation of an Ultrasensitive Assay, as Indicators of Doxorubicin-induced Cardiotoxicity2013 · 77 citations
  3. 3Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes2017 · 389 citations
  4. 4HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner2017 · 28 citations
  5. 5Potential effects of pomegranate on lipid peroxidation and pro-inflammatory changes in daunorubicin-induced cardiotoxicity in rats2016 · 38 citations