Why the study?
Doxorubicin is an effective broad-spectrum anti-cancer drug, but its clinical use can be limited by cardiotoxicity.
Does Panax ginseng reduce doxorubicin-induced cardiotoxicity in male Sprague Wistar rats?
Population
Thirty male Sprague Wistar rats
Comparison
Distilled water plus saline vs distilled water plus doxorubicin vs Panax ginseng plus doxorubicin
Design
Animal experimental study
Key result
Panax ginseng significantly reduced doxorubicin-induced myocardial injury in experimental rats, lowering cardiac troponin I levels by 9.89 ng/L compared to doxorubicin alone.
Authors
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Hypothesis-generating for ginseng in doxorubicin cardiotoxicity; requires human trials before any clinical consideration.
Does Panax ginseng reduce doxorubicin-induced cardiotoxicity in male Sprague Wistar rats?
Mean Difference: -9.89 (95% CI -15.7–-4.07)
Absolute Event Rate: 30.2% vs 40.09%
p-value: p=0.002
Panax ginseng attenuates doxorubicin-induced cardiotoxicity in a rat model by suppressing oxidative stress, inflammatory, and apoptotic pathways.
Al-Hussaniy et al. (2022) studied Doxorubicin-induced cardiotoxicity (n=30). Panax ginseng vs. Doxorubicin alone (20 mg/kg) was evaluated on Cardiac troponin I (cTnI) levels (MD -9.89, 95% CI -15.70-4.07, p=0.002). Panax ginseng significantly reduced doxorubicin-induced myocardial injury in experimental rats, lowering cardiac troponin I levels by 9.89 ng/L compared to doxorubicin alone.
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