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August 11, 2025PharmaceuticsOpen Access

Potential of Pumpkin Pulp Carotenoid Extract in the Prevention of Doxorubicin-Induced Cardiotoxicity

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Authors

MBMilana BosanacUniversity of Novi SadASAlena StuparUniversity of Novi SadBCBiljana CvetkovićUniversity of Novi Sad

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Overview

Experimental analysis shows pumpkin pulp extract mitigates doxorubicin-induced cardiotoxicity in rats, highlighting the Nrf2 pathway's role.

Key Points

  • Pumpkin pulp extract significantly improved general health and heart function in doxorubicin-treated rats, compared to controls.
  • NT-proBNP, CK-MB, and hsTnT levels were notably elevated in animals receiving doxorubicin alone, indicating cardiac stress.
  • Analysis involved Wistar rats divided into groups based on treatments, assessing heart function and tissue damage scores.
  • Restoring Nrf2 expression was linked to the cardioprotective effects of carotenoids in pumpkin pulp extract, suggesting therapeutic potential.

Cite This Study

Bosanac et al. (2025) studied this question.

synapsesocial.com/papers/68a360e70a429f79733298ddhttps://doi.org/10.3390/pharmaceutics17080977
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  4. 4Exploring the Antioxidant and Anti-inflammatory Effects of Pumpkin and Olive Oil on Doxorubicin-induced Renal Toxicity in Rats2026
  5. 5Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach2021 · 27 citations