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May 17, 2021Frontiers in PharmacologyOpen Access

Dillenia pentagyna hydroalcoholic extract significantly improved cardiac functionality and reduced oxidative stress via the Nrf-2 pathway in a mouse model of doxorubicin-induced cardiotoxicity.

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Why the study?

Does Dillenia pentagyna extract attenuate doxorubicin-induced cardiotoxicity in preclinical models?

Population

H9c2 cell line and balb/c mice subjected to a doxorubicin-induced cardiotoxicity model

Comparison

Pre-treatment with Dillenia pentagyna bark… vs Doxorubicin control group

Design

Preclinical

Key result

Dillenia pentagyna hydroalcoholic extract significantly improved cardiac functionality and reduced oxidative stress via the Nrf-2 pathway in a mouse model of doxorubicin-induced cardiotoxicity.

Authors

KTKalyani TeneMKM. Kalyan KumarGBG. Basveshwar

Discussion

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Member takes

Overview

Preclinical data only; leaves open whether Dillenia pentagyna protects patients from doxorubicin cardiotoxicity.

Structured PICO

Does Dillenia pentagyna extract attenuate doxorubicin-induced cardiotoxicity in preclinical models?

P
Population
24 male Balb/c mice were used to evaluate the cardioprotective effects of Dillenia pentagyna hydroalcoholic extract against doxorubicin-induced cardiotoxicity over 14 days.
I
Intervention
Pre-treatment with Dillenia pentagyna (DP) bark extracts/fractions (hydroalcoholic extract and phenolic-rich fraction F1)
C
Comparator
Doxorubicin (Dox) control group (no DP pre-treatment)
O
Outcome
Cardiac functionality (left ventricular ejection fraction and stroke volume), electrocardiogram parameters, cell viability, ROS levels, and cytoprotective protein expression (HO-1, SOD-2, Nrf-2)surrogate

Polyphenolic-rich extracts from Dillenia pentagyna demonstrate cardioprotective effects against doxorubicin-induced toxicity in preclinical models, suggesting potential as a therapeutic adjunct.

Limitations

  • Lack of pharmacokinetic and pharmacodynamic parameter understanding for clinical translation

Cite This Study

Tene et al. (2021) studied Doxorubicin-induced cardiotoxicity (n=24). Dillenia pentagyna Roxb (DP) hydroalcoholic extract vs. Doxorubicin alone (disease control) was evaluated on Cardiac functional parameters (ejection fraction, stroke volume) and oxidative stress markers. Dillenia pentagyna hydroalcoholic extract significantly improved cardiac functionality and reduced oxidative stress via the Nrf-2 pathway in a mouse model of doxorubicin-induced cardiotoxicity.

synapsesocial.com/papers/6ab4ac898ac9efd36c9eebaahttps://doi.org/10.3389/fphar.2021.624706
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Also Consider

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