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March 20, 2021AnimalsOpen Access

Date Palm Pollen Extract Avert Doxorubicin-Induced Cardiomyopathy Fibrosis and Associated Oxidative/Nitrosative Stress, Inflammatory Cascade, and Apoptosis-Targeting Bax/Bcl-2 and Caspase-3 Signaling Pathways

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Why the study?

Doxorubicin causes dose-dependent cardiotoxicity that restricts its clinical application, prompting investigation into whether date palm pollen ethanolic extract could ameliorate these cardiotoxic effects.

Does date palm pollen ethanolic extract ameliorate doxorubicin-induced cardiotoxicity in a rat model?

Population

Forty male Wistar albino rats

Comparison

Control vs DPPE vs DOX vs DPPE + DOX

Design

Preclinical animal study

Authors

SESamar S. ElblehiYEYasser El‐SayedMSMohamed Mohamed Soliman

Discussion

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Overview

DPPE may attenuate DOX cardiotoxicity in rats; hypothesis-generating and leaves open translation to clinical oncology.

Structured PICO

Does date palm pollen ethanolic extract ameliorate doxorubicin-induced cardiotoxicity in a rat model?

P
Population
40 male Wistar albino rats
I
Intervention
Date palm pollen ethanolic extract (DPPE) 500 mg/kg body weight for 4 weeks pre-coadministered with doxorubicin
C
Comparator
Doxorubicin alone (2.5 mg/kg body weight, intraperitoneally six times over 2 weeks), DPPE alone, and untreated control
O
Outcome
Cardiac injury markers (serum aminotransferases, LDH, CK, CK-MB, cTnI, cTnT, NT-pro BNP, cytosolic Ca+2), oxidative/nitrosative stress, inflammatory markers, and histopathological/apoptotic changessurrogate

Date palm pollen extract demonstrates potential in mitigating doxorubicin-induced cardiotoxicity in a preclinical model via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.

Cite This Study

Elblehi et al. (2021) studied this question.

synapsesocial.com/papers/6a71672ca528af2d65c40f54https://doi.org/10.3390/ani11030886
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 42004 · 48 citations
  2. 2Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach2021 · 27 citations
  3. 3Cistanche deserticola Polysaccharides Protect Against Doxorubicin-Induced Cardiotoxicity via Antioxidant and Mitochondrial Mechanisms2025 · 1 citations
  4. 4Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats2016 · 9 citations
  5. 5Exploring the cardioprotective potential of Hyphaene Thebaica L. extract, Bacillus-derived proteases, and vitamin E against doxorubicin-induced cardiotoxicity: Insights into mechanisms and Wnt/β-catenin/GSK3β signaling modulation2026 · 1 citations