NMR analysis of fluorinated corticosteroids related to fluocinonide: Detection of long‐range ¹H–¹⁹F couplings using the heteronuclear equivalent of the COSY experiment

The analysis of the 1 H and 19 F NMR spectra of the corticosteroid fluocinonide and five related steroids is reported. The 500 MHz 1 H NMR spectra revealed several previously undetected long‐range 1 H– 19 F coupling constants. These couplings were assigned by the application of the heteronuclear equivalent of the COSY pulse sequence. The fluorine substituent effects and long‐range heteronuclear couplings were examined in relation to structures derived from molecular mechanics (MMX) calculations.