Why the study?
Obstructive sleep apnea is associated with insulin resistance and type 2 diabetes, but whether it adversely impacts pancreatic islet beta-cell function remains unclear.
Does obstructive sleep apnea or short sleep duration affect insulin sensitivity or β-cell function in overweight/obese adults with prediabetes or untreated type 2 diabetes?
Comparison
Measures of OSA severity and actigraphy-derived sleep duration
Design
Baseline cross-sectional analysis of a clinical trial
Authors
Loading...
OSA severity linked to higher HbA1c but not insulin sensitivity or β-cell function in prediabetes; hypothesis-generating and should not yet change practice.
Does obstructive sleep apnea or short sleep duration affect insulin sensitivity or β-cell function in overweight/obese adults with prediabetes or untreated type 2 diabetes?
In adults with prediabetes or untreated type 2 diabetes, OSA is highly prevalent and associated with higher HbA1c, but not with impaired insulin sensitivity or β-cell function.
Mokhlesi et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: