Colchicine Reduces Postoperative Atrial Fibrillation
Why the study?
Does colchicine reduce the incidence of postoperative atrial fibrillation in patients after cardiac surgery?
Population
336 patients post-cardiac surgery, in sinus rhythm before starting the intervention, mean age 65.7±12.3…
Comparison
Colchicine 1.0 mg twice daily starting on… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
1 month
Authors
Discussion
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Member takes
Implication
Supports colchicine for POAF prevention after cardiac surgery; extends anti-inflammatory prophylaxis evidence.
Structured PICO
Does colchicine reduce the incidence of postoperative atrial fibrillation in patients after cardiac surgery?
P
Population
336 patients post-cardiac surgery, in sinus rhythm before starting the intervention, mean age 65.7±12.3 years, 69% male.
I
Intervention
Colchicine 1.0 mg twice daily starting on postoperative day 3 followed by a maintenance dose of 0.5 mg twice daily for 1 month (halved doses for patients <70 kg or intolerant to the highest dose).
C
Comparator
Placebo
O
Outcome
Incidence of postoperative atrial fibrillation (POAF) on intervention at 1 monthhard clinical
Colchicine administered postoperatively significantly reduces the incidence of postoperative atrial fibrillation and shortens hospital and rehabilitation stays in patients undergoing cardiac surgery.
Cite This Study
Imazio et al. (2011) studied this question.