Population
Voltage-clamped barnacle single muscle fibers
Comparison
Stretching the muscle during the declining phase… vs Control conditions
Design
Preclinical
Authors
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Animal stretch-calcium data require validation before any clinical extrapolation; leaves open cross-bridge modulation of calcium affinity in vivo.
Stretching active muscle fibers during the declining phase of the calcium transient produces biphasic changes in calcium binding, suggesting cross-bridge attachment and strain modify calcium affinity.
Gordon et al. (1990) studied this question.
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