Why the study?
Does prior anthracycline therapy for childhood malignancies alter transmural myocardial strain and rotation gradients compared to controls?
Population
32 anthracycline-treated survivors of childhood malignancies (aged 19.3 ± 5.4 years) and 28 controls
Comparison
Prior anthracycline therapy for childhood… vs Controls (no prior anthracycline therapy)
Design
Cross-sectional
Authors
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Supports layer-specific strain detection of subclinical impairment in survivors; leaves open prognostic value and need for prospective validation.
Does prior anthracycline therapy for childhood malignancies alter transmural myocardial strain and rotation gradients compared to controls?
Anthracycline-treated survivors of childhood cancers show preferential impairment of subendocardial circumferential deformation and apical rotation, which can be detected using layer-specific speckle tracking echocardiography.
Yu et al. (2012) studied this question.
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