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April 23, 2025Lipids in Health and DiseaseOpen Access

The association between Glycated Hemoglobin to High Density Lipoprotein Cholesterol Ratio and risk of cardiovascular diseases caused death among adult cancer survivors: evidence from NHANES 1999–2018

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Why the study?

Cancer survivors face an elevated risk of CVD mortality, making the identification of biomarkers associated with CVDs in this growing population vital.

Does the Glycated Hemoglobin to High Density Lipoprotein Cholesterol Ratio (GH/HDL-C) predict cardiovascular disease mortality in adult cancer survivors?

Population

3,244 adult cancer survivors from NHANES (1999-2018)

Comparison

Higher vs lower GH/HDL-C ratio levels across age groups

Design

Retrospective cohort study

Follow-up

168 months

Authors

FSFan SunXYXiaoyan YuXHXiaohong Huang

Discussion

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Member takes

Overview

May inform CVD risk assessment in cancer survivors; leaves open whether GH/HDL-C predict outcomes prospectively.

Structured PICO

Does the Glycated Hemoglobin to High Density Lipoprotein Cholesterol Ratio (GH/HDL-C) predict cardiovascular disease mortality in adult cancer survivors?

P
Population
3,244 adult cancer survivors from NHANES (1999-2018) with comprehensive Glycated Hemoglobin (GH), High Density Lipoprotein Cholesterol (HDL-C), CVDs history and survival follow-up information.
I
Intervention
Glycated Hemoglobin to High Density Lipoprotein Cholesterol Ratio (GH/HDL-C) levels
C
Comparator
Lower GH/HDL-C levels or reference values
O
Outcome
Cardiovascular diseases (CVDs)-caused mortalityhard clinical

The GH/HDL-C ratio is a significant, age-dependent biomarker for predicting cardiovascular mortality risk in adult cancer survivors.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/6a7d4912c9ada5f6b9d5a547https://doi.org/10.1186/s12944-025-02566-x
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