Ulceration and Perforation of the Nasal Septum in Systemic Lupus Erythematosus

IN the two patients described below, ulceration and subsequent perforation of the nasal septum developed at the same time as acute exacerbation of systemic lupus erythematosus. Review of records from this institution revealed a third, similar case. No other cases of such occurrence were found in the literature.Case ReportsCase 1. A 25-year-old woman was admitted to the hospital in March, 1966. For 8 years she had noticed Raynaud's phenomenon later turning to persistent acrocyanosis. Since 1960, she had had episodes of erythematous rash, alopecia, sore throat, polyarthritis, fever and weight loss. In 1 episode 2 months before admission . . .