January 23, 2006Archives of Internal Medicine
Clinical Depression and Risk of Out-of-Hospital Cardiac Arrest
Why the study?
Is clinical depression associated with an increased risk of out-of-hospital cardiac arrest in adults aged 40 to 79 years?
Population
6,392 adults aged 40 to 79 years enrolled in a health maintenance organization in western Washington State.
Comparison
Presence of clinical depression. vs Absence of clinical depression.
Design
Case-control
Authors
Discussion
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Member takes
Implication
Supports depression screening in cardiac risk stratification; leaves open whether treatment modifies arrest incidence.
Structured PICO
Is clinical depression associated with an increased risk of out-of-hospital cardiac arrest in adults aged 40 to 79 years?
P
Population
6,392 adults aged 40 to 79 years (2,228 cases of out-of-hospital cardiac arrest and 4,164 controls) enrolled in a health maintenance organization in western Washington State.
I
Intervention
Presence of clinical depression (defined as physician diagnosis of depression or use of antidepressant treatment within the year before the event).
C
Comparator
Absence of clinical depression.
O
Outcome
Incident out-of-hospital cardiac arrest.hard clinical
Clinical depression is independently associated with an increased risk of out-of-hospital cardiac arrest, with the risk increasing alongside depression severity.
Cite This Study
Empana et al. (2006) studied this question.