Population
Human endothelial progenitor cells outgrown from human blood of healthy subjects, human umbilical vein…
Comparison
Exposure to oxidative stress and adenoviral… vs HUVECs and CAECs or cells without MnSOD…
Design
Preclinical
Authors
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May bolster EPC resilience in oxidative vascular injury; hypothesis-generating for MnSOD-targeted regeneration, pending in vivo validation.
Human endothelial progenitor cells are intrinsically resistant to oxidative stress due to high expression of manganese superoxide dismutase, which may explain their regenerative capacity in injured vessels.
He et al. (2004) studied this question.
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