Why the study?
Does high job stress increase the risk of elevated hs-CRP levels in Chinese workers?
Does high job stress increase the risk of elevated hs-CRP levels in Chinese workers?
High job stress, characterized by effort-reward imbalance and overcommitment, is associated with elevated hs-CRP levels, suggesting inflammation as a mediator between job stress and atherosclerosis.
May indicate inflammation mediating job stress and CVD risk; leaves open causality and whether reducing ERI lowers hs-CRP prospectively.
BACKGROUND: Chronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers. METHODS: A total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model. RESULTS: Among men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P<0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P<0.05). CONCLUSIONS: High effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis.
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Xu et al. (2015) studied this question.
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