What question did this study set out to answer?

To determine the timing and origins of childhood weight gain linked to impaired glucose tolerance and type 2 diabetes mellitus in young adulthood.

February 25, 2004New England Journal of MedicineOpen Access

Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood

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Authors

SBSantosh K. BhargavaLucile Packard Children's Hospital HSHarshpal Singh SachdevSitaram Bhartia Institute of Science and Research CFCaroline FallHuman Sciences Research Council

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Implication

Prospective cohort study reveals childhood growth trajectories link to adult glucose intolerance, suggesting early rapid weight gain elevates diabetes risk.

Key Points

To determine the timing and origins of childhood weight gain linked to impaired glucose tolerance and type 2 diabetes mellitus in young adulthood.
Prospective, population-based cohort study evaluating 1492 men and women aged 26 to 32 years.
Anthropometric measurements were taken at birth and every 3 to 6 months throughout infancy, childhood, and adolescence.
Adult outcomes assessed included glucose tolerance and plasma insulin concentrations.
The overall prevalence was 10.8% for impaired glucose tolerance and 4.4% for type 2 diabetes.
Individuals with impaired glucose tolerance or diabetes typically had low BMI up to age 2, followed by early adiposity rebound and rapid BMI gains, though none were obese at age 12.
An increase in BMI of 1 SD between ages 2 and 12 years was significantly associated with disease (OR 1.36, 95% CI 1.18 to 1.57, P<0.001).

Cite This Study

Bhargava et al. (2004) studied this question.

synapsesocial.com/papers/6a7d4e6dec6dad7f5aaa134d https://doi.org/10.1056/nejmoa035698

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Implication

Prospective cohort study reveals childhood growth trajectories link to adult glucose intolerance, suggesting early rapid weight gain elevates diabetes risk.

Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood

Discussion

Member takes

Implication

Key Points

Cite This Study

Relation of Serial Changes in Childhood Body-Mass Index to Impaired Glucose Tolerance in Young Adulthood

Discussion

Member takes

Implication

Key Points

Cite This Study

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