Pan-cancer bioinformatic analysis reveals CORO2A overexpression correlates with poor survival and altered immune infiltration in human malignancies, highlighting its role as a prognostic biomarker.
Background. Coronin 2A (CORO2A) is a member of the coronin family and reportedly functions as an oncogene in certain malignancies, although its correlation with prognosis and immune infiltration in different cancers remains unclear. Methods. Data were collected from the University of California Santa Cruz (UCSC), Human Protein Atlas (HPA), Tumor Immune Estimation Resource (TIMER), Tumor-Immune System Interactions (TISIDB) and Gene Set Enrichment Analysis (GSEA) databases. The differential expression of CORO2A, survival, clinical parameters, tumor mutational burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) genes, DNA methyltransferases (DNMTs), tumor microenvironment (TME), immune-related genes (IRGs), immune infiltration, pathways and functions were analyzed using the R language software. Results. CORO2A was overexpressed in various malignancies, and correlated with clinical parameters, overall survival, disease-specific survival and progression-free survival in certain cancers. Furthermore, CORO2A was significantly correlated to the TMB, MSI, MMR genes, DNMTs, immune and stromal scores, IRGs and immune infiltration. GSEA further showed that CORO2A was associated with various immune-related pathways and functions in different cancer types. Conclusion. CORO2A is a promising prognostic and immunological marker for human cancers.
No takes yet. Share an insight, caveat, or question.
Xie et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: