The Effect of Prepubertal Androgen Exposure on Adult Penile Length

No AccessJournal of UrologyAndrology/Testes1 Aug 1996The Effect of Prepubertal Androgen Exposure on Adult Penile Length Ronald S. Sutherland, Barry A. Kogan, Laurence S. Baskin, Robert A. Mevorach, Felix Conte, Selna L. Kaplan, and Melvin M. Grumbach Ronald S. SutherlandRonald S. Sutherland , Barry A. KoganBarry A. Kogan , Laurence S. BaskinLaurence S. Baskin , Robert A. MevorachRobert A. Mevorach , Felix ConteFelix Conte , Selna L. KaplanSelna L. Kaplan , and Melvin M. GrumbachMelvin M. Grumbach View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65814-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Recent studies in the rat suggest that early exposure to exogenous testosterone accelerates the loss of androgen receptors and compromises eventual penile length. To determine whether this is true in men we measured adult penile length of patients treated in childhood for sexual precocity. Materials and Methods: We examined 21 men with sexual precocity due to true precocious puberty (12) or congenital adrenal hyperplasia (9) who had been followed at our institution since childhood. Penile lengths were compared with data from normal men. Results: Mean stretched penile length plus or minus standard deviation was 12.7 plus/minus 2.6 cm. in all patients, 12.1 plus/minus 2.6 cm. in those with true precocious puberty and 13.6 plus/minus 1.6 cm. in those with congenital adrenal hyperplasia. These lengths were not significantly different from those of normal men (12.4 plus/minus 2.7 cm.). Conclusions: In contrast to findings in rats, exposure to endogenous testosterone during gestation and/or childhood does not reduce adult penile length in men. 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Google Scholar From the Departments of Urology and Pediatrics, University of California School of Medicine, San Francisco, California.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byHusmann D (2018) EDITORIAL: MICROPHALLIC HYPOSPADIAS-THE USE OF HUMAN CHORIONIC GONADOTROPIN AND TESTOSTERONE BEFORE SURGICAL REPAIRJournal of Urology, VOL. 162, NO. 4, (1440-1441), Online publication date: 1-Oct-1999.Baskin L, Sutherland R, DiSandro M, Hayward S, Lipschutz J and Cunha G (2018) The Effect of Testosterone on Androgen Receptors and Human Penile GrowthJournal of Urology, VOL. 158, NO. 3, (1113-1118), Online publication date: 1-Sep-1997. Volume 156Issue 2SAugust 1996Page: 783-787 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Ronald S. Sutherland More articles by this author Barry A. Kogan More articles by this author Laurence S. Baskin More articles by this author Robert A. Mevorach More articles by this author Felix Conte More articles by this author Selna L. Kaplan More articles by this author Melvin M. Grumbach More articles by this author Expand All Advertisement PDF downloadLoading ...