Why the study?
Are serum total calcium, ionized calcium, and albumin levels altered in patients with essential hypertension and their first-degree relatives compared to normotensive controls?
Are serum total calcium, ionized calcium, and albumin levels altered in patients with essential hypertension and their first-degree relatives compared to normotensive controls?
Serum total calcium and albumin levels are significantly decreased in patients with essential hypertension and their first-degree relatives, suggesting a potential pathophysiological link.
May link familial hypocalcemia to essential hypertension risk; hypothesis-generating and should not change practice without prospective data.
Calcium plays an important role in pathophysiology of essential hypertension. (1) Serum total calcium, serum ionized calcium and serum albumin levels were measured in 50 subjects with essential hypertension and 50 first degree relatives with familial history of hypertension. The same were also measured in 50 normotensive subjects and 50 first degree relatives having no familial history of hypertension. The results showed that serum total calcium and serum albumin levels were significantly decreased in both males and females with essential hypertension and their first degree relatives when compared with their corresponding controls. While serum ionized calcium levels were not significantly different in hypertensives and their first degree relatives.
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Patel et al. (2014) studied this question.
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