Synthesis of quinolin‐4‐yl substituted malonates, cyanoacetates, acetoacetates and related compounds

Abstract magnified image 4‐Chloro‐ or 4‐tosyloxyquinolines 1 and 10 react with CH‐acidic compounds such as malonates 2a,b , ethyl cyanoacetate ( 2c ), malononitrile ( 2d ), ethyl acetoacetate ( 2e ), acetylacetone ( 2f ) or dimedone ( 2g ) under mild conditions and good yields to quinolin‐4‐yl substituted derivatives 3‐8 and 11 . With 3‐phenylsulfonylquinolones 1i‐k a redox reaction to 2‐hydroxy‐2‐quinolin‐4‐yl‐malonates 9 was observed. Amination of 3‐nitroquinolinyl malonate 3f leads to malonester‐amides 13 and 14 .