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September 1, 1981The Journal of Experimental MedicineOpen Access

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

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Authors

MPMichael K. PangburnThe University of Texas Health Science Center at Tyler
Robert D. Schreiber
Robert D. SchreiberRoche (Switzerland)HMHans J. Müller‐EberhardRockefeller Foundation

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Pangburn et al. (1981) studied this question.

synapsesocial.com/papers/6a7d52d02f2f9d79738b2e8ahttps://doi.org/10.1084/jem.154.3.856
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement.1980 · 335 citations
  2. 2Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties1981 · 188 citations
  3. 3THE C3-ACTIVATOR SYSTEM: AN ALTERNATE PATHWAY OF COMPLEMENT ACTIVATION1971 · 940 citations
  4. 4Initiation of C3 Cleavage in the Alternative Complement Pathway1975 · 70 citations
  5. 5Hemolytic Activity of Lipoprotein-Depleted Serum and the Effect of Certain Anions on Complement1966 · 66 citations