What question did this study set out to answer?

To assess the relationship between body mass index, standard cardiovascular risk factors, and cardiovascular disease mortality across European cohorts.

June 3, 2011European Journal of Cardiovascular Prevention & RehabilitationOpen Access

Relationships between body mass index, cardiovascular mortality, and risk factors: a report from the SCORE investigators

View Full Paper

Ask AI

Bookmark

Why the study?

Is body mass index associated with cardiovascular mortality and other risk factors in a European cohort?

Population

Participants from 12 European cohort studies in the Systematic Coronary Risk Evaluation data set, stratified…

Comparison

Body mass index as a continuous variable and in… vs Lower BMI categories / continuous comparison

Design

Cohort

Authors

ADAlexandra DudinaChurchill Hospital MCMarie Therese CooneyPreventive Cardiology DBDirk De BacquerPreventive Cardiology

Discussion

Member takes

Implication

BMI-CVD mortality link may reflect diabetes/HDL mediation; leaves open independent adiposity effects in European cohorts.

Key Points

To assess the relationship between body mass index, standard cardiovascular risk factors, and cardiovascular disease mortality across European cohorts.
Analyzed pooled data from 12 European cohort studies within the Systematic Coronary Risk Evaluation (SCORE) project.
Evaluated univariable and multivariable Cox proportional hazards models across body mass index categories stratified by sex and age groups (<40, 40-49, 50-59, and >60 years).
A J-shaped relationship was observed where each 5-unit increase in body mass index increased cardiovascular mortality by 34% in men and 29% in women.
Hazard ratios remained significant after adjusting for age, smoking, total cholesterol, and systolic blood pressure, but the association attenuated entirely when further adjusting for diabetes and high-density lipoprotein cholesterol.
Each 1-unit increase in body mass index was associated with a 1.14 mmHg increase in systolic blood pressure, a 0.055 mmol/l increase in total cholesterol, and a 0.024 mmol/l decrease in HDL cholesterol in men, with comparable shifts in women.

Structured PICO

Is body mass index associated with cardiovascular mortality and other risk factors in a European cohort?

Population

Participants from 12 European cohort studies in the Systematic Coronary Risk Evaluation (SCORE) data set, stratified by age (<40, 40-49, 50-59, >60) and gender.

Intervention

Body mass index (BMI) as a continuous variable and in categories

Comparator

Lower BMI categories / continuous comparison

Outcome

Cardiovascular (CVD) mortalityhard clinical

Overweight and obesity are strongly associated with CVD mortality, particularly in younger individuals and women, though this risk appears largely mediated through other conventional risk factors like diabetes and HDL.

Cite This Study

Dudina et al. (2011) studied this question.

synapsesocial.com/papers/6a7d53551b8ecc4e56964b90 https://doi.org/10.1177/1741826711412039

View Full Paper

Ask AI

Bookmark

Relationships between body mass index, cardiovascular mortality, and risk factors: a report from the SCORE investigators

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Relationships between body mass index, cardiovascular mortality, and risk factors: a report from the SCORE investigators

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider