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Supports integrative triglyceride metabolism models; leaves open whether LCAT modulation affects clinical outcomes.
There is evidence that not only lipoprotein lipase (LPL) but also lecithin:cholesterol acyl transferase (LCAT) are involved in the directional flow of triglyceride (TG) from endogenous very low density lipoproteins (VLDL) and chylomicrons as part of a general energy storage pathway. Evidence is given to suggest that LCAT plays an integrative role in this process.
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Cramp et al. (1978) studied this question.
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