August 3, 2004Journal of Biological ChemistryOpen Access

Evaluation of the Contribution of Different ADAMs to Tumor Necrosis Factor α (TNFα) Shedding and of the Function of the TNFα Ectodomain in Ensuring Selective Stimulated Shedding by the TNFα Convertase (TACE/ADAM17)

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Population

Mouse embryonic fibroblasts lacking ADAMs 9, 10, 17 (TACE), or 19

Design

Preclinical

Authors

YZYufang ZhengFudan University PSPaul SäftigUniversity of Bern DHDieter HartmannClemson University

Discussion

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Implication

Animal fibroblast data on ADAM17/19 in TNFα release warrant no clinical changes; leaves open human therapeutic relevance.

Structured PICO

Population

Mouse embryonic fibroblasts lacking ADAMs 9, 10, 17 (TACE), or 19

Intervention

Phorbol ester (PMA) and pervanadate stimulation, overexpression of ADAMs (9, 10, 19), and mutagenesis of TNFalpha

Outcome

TNFalpha shedding/releasesurrogate

This study elucidates the specific roles of ADAM17 and ADAM19 in TNFalpha shedding and highlights the inhibitory role of the TNFalpha ectodomain against non-specific cleavage.

Cite This Study

Zheng et al. (2004) studied this question.

synapsesocial.com/papers/6a7d545e149bd8e2c5749d95 https://doi.org/10.1074/jbc.m403193200

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Evaluation of the Contribution of Different ADAMs to Tumor Necrosis Factor α (TNFα) Shedding and of the Function of the TNFα Ectodomain in Ensuring Selective Stimulated Shedding by the TNFα Convertase (TACE/ADAM17)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evaluation of the Contribution of Different ADAMs to Tumor Necrosis Factor α (TNFα) Shedding and of the Function of the TNFα Ectodomain in Ensuring Selective Stimulated Shedding by the TNFα Convertase (TACE/ADAM17)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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