Population
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels (specifically HCN1)
Comparison
Systematic length alterations of the S3-S4 linker vs Wild type HCN channels
Design
Preclinical
Authors
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May inform HCN-based biological pacemaker engineering; leaves open validation in mammalian models.
The length and constituents of the S3-S4 linker, particularly the essential Met232 residue, shape the activation phenotype of HCN pacemaker channels, which could inform engineering of biological pacemakers.
Tsang et al. (2004) studied this question.
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