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To determine the antimicrobial resistance profiles of clinical bacterial isolates against third-generation cephalosporins in a hospital setting.

September 9, 2018Journal of PharmaceuticsOpen Access

Antimicrobial Resistance Profile of Different Clinical Isolates against Third-Generation Cephalosporins

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Prospective cross-sectional study observes high cephalosporin resistance in hospitalized patients, indicating widespread multidrug resistance.

To determine the antimicrobial resistance profiles of clinical bacterial isolates against third-generation cephalosporins in a hospital setting.
Conducted a prospective cross-sectional study from April to August 2016 at Jimma University Specialized Hospital.
Collected wound swab, urine, sputum, and stool specimens from hospitalized patients (N=248 bacterial isolates; 62.1% male, 37.9% female).
Identified bacterial species using standard microbiological protocols and evaluated antimicrobial susceptibility using the Kirby–Bauer disc diffusion method.
Escherichia coli (25.4%) and Staphylococcus aureus (19.0%) were the most prevalent isolates.
Resistance rates reached 56.5% (140/248) for ceftriaxone and 60.1% (149/248) for ceftazidime across all isolates; among E. coli isolates, resistance was 73% (46/63) to ceftriaxone and 65% (41/63) to ceftazidime.
Multidrug resistance was common, with 44% (109/248) of ceftriaxone-resistant strains and 43.5% (108/248) of ceftazidime-resistant strains exhibiting resistance to two, three, or four additional antimicrobial agents.

Gashe et al. (2018) studied this question.

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Prospective cross-sectional study observes high cephalosporin resistance in hospitalized patients, indicating widespread multidrug resistance.