What question did this study set out to answer?

Identify and characterize carbapenem-resistant Klebsiella pneumoniae isolates carrying the bla-KPC carbapenemase gene in an Italian hospital setting.

January 1, 2010BMC Research NotesOpen Access

Emergence of KPC-producing Klebsiella pneumoniae in Italy

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Authors

CFCarla FontanaIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani MFMarco FavaroUniversity of Rome Tor Vergata LSLoredana SarmatiUniversity of Rome Tor Vergata

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Implication

Surveillance report reveals carbapenem-resistant Klebsiella pneumoniae harboring the bla-KPC gene in hospitalized patients without foreign travel, indicating local transmission of...

Key Points

Identify and characterize carbapenem-resistant Klebsiella pneumoniae isolates carrying the bla-KPC carbapenemase gene in an Italian hospital setting.
Analyzed two carbapenem-resistant K. pneumoniae clinical isolates recovered from a central venous catheter and an indwelling urinary catheter in hospitalized patients with no history of travel abroad.
Assessed antimicrobial susceptibility profiles and performed phenotypic confirmation of carbapenemase activity using the Hodge test.
Conducted molecular analysis to detect the plasmid-borne bla-KPC gene.
Both isolates harbored the bla-KPC carbapenemase gene and were resistant to all tested beta-lactams and ertapenem, while remaining susceptible to imipenem and meropenem.
The isolates demonstrated multidrug resistance across quinolones, trimethoprim-sulfamethoxazole, nitrofurantoin, and aminoglycosides, with retained susceptibility observed only for amikacin.

Cite This Study

Fontana et al. (2010) studied this question.

synapsesocial.com/papers/6a7d55632935e92dbc7763c5 https://doi.org/10.1186/1756-0500-3-40

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Implication

Surveillance report reveals carbapenem-resistant Klebsiella pneumoniae harboring the bla-KPC gene in hospitalized patients without foreign travel, indicating local transmission of...

Emergence of KPC-producing Klebsiella pneumoniae in Italy

Discussion

Member takes

Implication

Key Points

Cite This Study

Emergence of KPC-producing Klebsiella pneumoniae in Italy

Discussion

Member takes

Implication

Key Points

Cite This Study

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