Curcumin‐Loaded Nanocapsules: Population Pharmacokinetic and Time‐to Event Modeling in Healthy Rats and LPS‐Induced Inflammation Flies

Curcumin (CUR) is a bioactive compound with antioxidant, anti‐inflammatory, and anticancer properties, though its clinical use is limited by low bioavailability, rapid metabolism, and poor solubility. To address these challenges, our study investigates nanoencapsulated curcumin (NC‐CUR) to enhance its pharmacokinetics and therapeutic efficacy, using Drosophila melanogaster as a preclinical model for chronic inflammation. We developed NC‐CUR with an average size of 196 nm, uniform distribution, and high encapsulation efficiency. Population pharmacokinetic (PopPK) modeling demonstrated improved bioavailability and prolonged systemic exposure of NC‐CUR in rodents. Using time‐to‐event (TTE) analysis, we further evaluated NC‐CUR's impact on survival in LPS‐induced inflammation in D. melanogaster . The TTE model confirmed that NC‐CUR significantly extended survival compared to CUR and control groups, revealing a cumulative protective effect. These findings suggest that TTE modeling is a valuable tool for investigating NC‐CUR's protective effects in chronic inflammation, warranting further studies in mammalian models to fully explore its therapeutic potential and translational relevance.