October 9, 2002European Heart JournalOpen Access

Neoplastic pericardial effusion. Efficacy and safety of intrapericardial treatment with cisplatin

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Why the study?

Does intrapericardial cisplatin prevent recurrence of neoplastic pericardial effusion in patients undergoing pericardiocentesis?

Population

42 patients with large neoplastic pericardial effusion undergoing pericardiocentesis selected from a…

Design

Cohort

Follow-up

6 months

Authors

BMBernhard MaischGeneral Cardiology

Discussion

Member takes

Implication

May support intrapericardial cisplatin after pericardiocentesis; leaves open need for RCTs to confirm benefit.

Structured PICO

Does intrapericardial cisplatin prevent recurrence of neoplastic pericardial effusion in patients undergoing pericardiocentesis?

Population

42 patients with large neoplastic pericardial effusion undergoing pericardiocentesis (69% males, mean age 58.8+/-13.2 years) selected from a registry of 260 patients.

Intervention

Intrapericardial treatment with cisplatin (single instillation of 30 mg/m2 x 24h) in addition to tumour-specific systemic chemotherapy.

Outcome

Recurrence of pericardial effusion at 3 and 6 months follow-up.

Intrapericardial cisplatin instillation is an effective and safe strategy for preventing the recurrence of neoplastic pericardial effusion, particularly in patients with lung cancer.

Cite This Study

Bernhard Maisch (2002) studied this question.

synapsesocial.com/papers/6a7d565a7786afdcaca011ea https://doi.org/10.1053/euhj.2002.3328

Topics

Women and heart disease

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Neoplastic pericardial effusion. Efficacy and safety of intrapericardial treatment with cisplatin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Neoplastic pericardial effusion. Efficacy and safety of intrapericardial treatment with cisplatin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider