What question did this study set out to answer?

To identify risk factors associated with postoperative septic complications after traumatic intestinal perforation and evaluate the comparative efficacy of single-drug versus dual-drug prophylactic antibiotic regimens.

October 25, 1984New England Journal of Medicine

Risk of Infection after Penetrating Abdominal Trauma

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Authors

RNRonald Lee NicholsHackensack University Medical Center JSJeffrey W. SmithMirati Therapeutics (United States)DKDaniel B. KleinUniversity of California, Berkeley

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Implication

Two-center comparative study identifies major risk factors for postoperative sepsis in intestinal trauma, indicating single-agent cefoxitin matches dual-drug antibiotic prophylaxis efficacy.

Key Points

To identify risk factors associated with postoperative septic complications after traumatic intestinal perforation and evaluate the comparative efficacy of single-drug versus dual-drug prophylactic antibiotic regimens.
Analyzed 145 patients presenting with abdominal trauma and intestinal perforation across two hospitals between July 1979 and June 1982.
Administered prophylactic antibiotic regimens of either single-agent cefoxitin or combination clindamycin plus gentamicin.
Performed univariate and multivariate logistic-regression analyses to determine independent predictors of postoperative infection.
Logistic-regression analysis revealed increased infection risk (P < 0.05) independently associated with older age, left colon injury requiring colostomy, increased units of blood products transfused during surgery, and a higher number of injured organs; initial shock provided no added predictive power.
Patients with postoperative sepsis had significantly longer hospital stays compared to those without infection (13.8 vs. 7.7 days, P < 0.0001).
Single-drug cefoxitin and dual-drug clindamycin plus gentamicin demonstrated comparable rates of infection, drug toxicity, hospital duration, and overall costs.

Cite This Study

Nichols et al. (1984) studied this question.

synapsesocial.com/papers/6a7d57c7ec6dad7f5aaa1512 https://doi.org/10.1056/nejm198410253111701

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Implication

Two-center comparative study identifies major risk factors for postoperative sepsis in intestinal trauma, indicating single-agent cefoxitin matches dual-drug antibiotic prophylaxis efficacy.

Risk of Infection after Penetrating Abdominal Trauma

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk of Infection after Penetrating Abdominal Trauma

Discussion

Member takes

Implication

Key Points

Cite This Study

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