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May 1, 2016Cold Spring Harbor Perspectives in BiologyOpen Access

Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating

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Population

Voltage-gated potassium channels (including KcsA and MthK)

Design

Review

Authors

DKDorothy M. KimRegeneron (United States)CNCrina M. NimigeanCornell University

Discussion

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Implication

Clarifies K channel gating mechanisms from structural data; leaves open clinical translation to arrhythmia therapies.

Structured PICO

P
Population
Voltage-gated potassium channels (including KcsA and MthK)
O
Outcome
Mechanisms of selectivity and gating

Provides a comprehensive structural and functional overview of how voltage-gated potassium channels achieve ion selectivity and voltage-dependent gating.

Cite This Study

Kim et al. (2016) studied this question.

synapsesocial.com/papers/6a7d5a24a3b6fd5035d5b294https://doi.org/10.1101/cshperspect.a029231
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  2. 2Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation2008 · 130 citations
  3. 3Potassium blocks barium permeation through a calcium-activated potassium channel.1988 · 227 citations
  4. 4Ion Binding Affinity in the Cavity of the KcsA Potassium Channel2004 · 89 citations