Population
Mouse corticotroph tumour cell line AtT20/D16-16 (n=83 cells: 52 control, 31 treated)
Comparison
Dexamethasone (100 nM, 2 h, 37 degrees C) vs Control cells
Design
Preclinical
Follow-up
2 hours
Authors
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Should not change clinical practice; extends rodent data on corticotroph ion channels but leaves open human ACTH regulation.
Dexamethasone selectively enhances the A type potassium current in corticotroph cells via new protein synthesis, contributing to the inhibitory control of ACTH secretion.
Pennington et al. (1994) studied this question.
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