Population
Hyplip2 congenic mouse strain (containing part of chromosome 15 from MRL/MpJ on the BALB/cJ background)
Comparison
Intravenous injection with glycerol… vs Control mice (implied by comparison values)
Design
Preclinical
Authors
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Supports LPL defect as hypertriglyceridemia driver in Hyplip2 mice; leaves open relevance to human disease.
The hypertriglyceridemia observed in the Hyplip2 mouse model is driven by decreased LPL-mediated triglyceride clearance rather than increased intestinal absorption or hepatic production.
Moen et al. (2007) studied this question.
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