Key result
CD36-deficient mice exhibited increased plasma triglyceride levels that were not due to differences in hepatic VLDL-TG production or intestinal TG uptake compared with wild-type littermates.
Population
CD36-deficient (cd36-/-) mice
Comparison
CD36 deficiency vs Wild-type littermates
Design
Preclinical
Authors
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May implicate peripheral TG clearance defects; leaves open translation of CD36 mouse findings to human hypertriglyceridemia.
CD36 deficiency in mice causes hypertriglyceridemia not by increasing VLDL production or intestinal uptake, but by impairing lipoprotein lipase-mediated triglyceride clearance due to elevated free fatty acids.
Goudriaan et al. (2005) studied CD36 deficiency. CD36 deficiency (cd36-/-) vs. Wild-type littermates was evaluated on Hepatic VLDL-TG production and intestinal TG uptake. CD36-deficient mice exhibited increased plasma triglyceride levels that were not due to differences in hepatic VLDL-TG production or intestinal TG uptake compared with wild-type littermates.
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