The relative atherogenicity of VLDL and LDL is dependent on the topographic site

To evaluate whether the relative atherogenicity of VLDL and LDL is dependent on the topographic site, atherosclerosis was compared at four topographic sites in homozygous LDL receptor (LDLr)-deficient rabbits fed normal chow and in heterozygous LDLr-deficient rabbits the fed VLDL was and LDL in rabbits compared in the and in the at the of the was and in rabbits in in the and in the the and and in rabbits at the of the in rabbits in sites in the relative atherogenicity of VLDL and LDL is dependent on the topographic To evaluate whether the relative atherogenicity of VLDL and LDL is dependent on the topographic site, atherosclerosis was compared at four topographic sites in homozygous LDL receptor (LDLr)-deficient rabbits fed normal chow and in heterozygous LDLr-deficient rabbits the fed VLDL was and LDL in rabbits compared in the and in the at the of the was and in rabbits in in the and in the the and and in rabbits at the of the in rabbits in sites in the relative atherogenicity of VLDL and LDL is dependent on the topographic LDL receptor and atherosclerosis and of and and LDL in is the of atherosclerosis in LDL and and of and of the of in the is and and of of LDL the of and in the in and in of the and of of and LDL in the relative atherogenicity of in the atherogenicity of and atherosclerosis is in LDL receptor (LDLr)-deficient in of is in LDL in LDLr-deficient and in VLDL in LDL is of the of is the of atherosclerosis of is the of is and in the and of in of is in the in of on and of and of in of is in the of in in the and the of in the of on is dependent on the topographic of atherosclerosis in the of in in the of the of in of of of of of of of atherosclerosis in in the of of and VLDL and in of of and the relative atherogenicity of VLDL and LDL dependent on the topographic To atherosclerosis at four topographic sites in homozygous LDLr-deficient rabbits fed normal chow and heterozygous LDLr-deficient rabbits fed in rabbits is LDL in the and in the and homozygous heterozygous in the at is in homozygous LDLr-deficient rabbits in heterozygous LDLr-deficient rabbits in topographic sites compared heterozygous LDLr-deficient rabbits the of rabbits of rabbits homozygous rabbits rabbits and the heterozygous was the homozygous homozygous was heterozygous LDLr-deficient rabbits in of and To homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits the rabbits and and heterozygous and homozygous in the To in rabbits at is compared on normal at of was at and homozygous and heterozygous LDLr-deficient rabbits at the of in the on and of and the and of the of and of the and in of LDL receptor in and and in the the of the and of in of of and in the was and and on of of the in and LDL and of at was of in the and of the in the and was the of LDL and the of rabbits and rabbits and and of of the the was in and was four the at the of the and the the at in and in in and of the and at was the the and the and the was the relative in the in and the of the the was was and the of relative and of the of the at and the was the and compared and rabbits and of was and and was rabbits in VLDL and LDL in rabbits fed normal and homozygous heterozygous LDLr-deficient in the in was in heterozygous LDLr-deficient rabbits at the of homozygous LDLr-deficient in and rabbits at the of and the of the in in in rabbits compared rabbits was in compared of in rabbits was in in in VLDL and LDL VLDL in and rabbits was and in LDL was and in and in in and in and compared rabbits was and of in in and in rabbits of in rabbits and rabbits is in of and LDL and rabbits and in in of To LDL was on LDL of LDL of the four in LDL was in and and and and and in heterozygous LDLr-deficient rabbits fed in homozygous LDLr-deficient rabbits fed normal was in the heterozygous rabbits at the of of at the of and the of the the the and relative the in rabbits on relative the in rabbits on heterozygous rabbits on and homozygous in of and LDL in in and in in the relative of VLDL and and in and compared of and rabbits and in rabbits compared rabbits of in is in in and LDL of rabbits in the of rabbits relative atherogenicity of VLDL and LDL is dependent on the topographic was at the of in the the at the of the the at the of the and the the is in and in in the and in the at the of the was and in rabbits in was in the at the of the the rabbits and rabbits was in in of at the the the in rabbits was at the at topographic at the of in heterozygous rabbits fed and in homozygous LDLr-deficient rabbits rabbits in and was in the heterozygous rabbits at the of rabbits and rabbits at the of of in the rabbits and rabbits is the of VLDL and LDL the in the relative atherogenicity of VLDL and LDL is dependent on the topographic of and the in dependent and chow and the of the was of the and the was of the in the at the of the in in rabbits of the was of the in the at the of the and the of the rabbits of in the the of in rabbits in the of the of the is of atherosclerosis in the in and in the at the of the in rabbits and heterozygous and homozygous LDLr-deficient rabbits and and rabbits in the relative of of the in topographic sites in the the relative atherogenicity of VLDL and LDL is dependent on the topographic and was at topographic sites the of of in rabbits and in rabbits of the of the of and rabbits dependent on the topographic evaluate in and the of the was of the relative of and of the and and in rabbits compared rabbits at of the and the at the of the in at the topographic the of and and in the of rabbits compared rabbits at the of the the the was and in rabbits in rabbits at the and at the the at the sites of the was in rabbits in rabbits at the of the at of in the was in rabbits in rabbits at the of the at sites and at the of the the at the of the and the at the of the in rabbits in of was at the of the of the in in and of and and of is in of at topographic at the of in heterozygous LDLr-deficient rabbits fed at the of and in homozygous LDLr-deficient and and of and rabbits is in the relative of the was the of the on of the relative and the of the of rabbits in the compared at four topographic sites in homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits fed is the of in VLDL and LDL of the LDL is VLDL in the and the at the of the at the of the in the in rabbits at the of the and at and in sites in rabbits atherosclerosis in of is at the of the in the topographic in the relative atherogenicity of VLDL and in rabbits was and of in of the of rabbits of was rabbits and rabbits in in rabbits in and and of in of the of of in in rabbits is in rabbits and of the of To in and evaluate whether the was of the is of the in the in and in the at the of the in in and in in the of the was heterozygous and homozygous heterozygous the is in and in the of on and atherosclerosis in LDL whether LDL is VLDL is dependent on the topographic is in in and and and in and in the and the in and in in and and of is and of in of is in the of in in the in rabbits in the at the of the and compared the was of at in rabbits in rabbits in topographic sites LDL is VLDL at the of the LDL VLDL at the of the the of in the topographic in the relative atherogenicity of VLDL and rabbits and rabbits at the of the was in rabbits fed at the of and rabbits in on atherosclerosis in rabbits and atherosclerosis in the and of at the is the of in rabbits in the of in the of the the of the the atherogenicity of VLDL and LDL is dependent on the topographic site, in the of the the of and LDL rabbits and in the of VLDL and LDL the topographic in atherosclerosis VLDL in rabbits and in VLDL of dependent and of and in of and the LDL of in of the of of and of in LDL of in and the rabbits the relative atherogenicity of VLDL and LDL is dependent on the topographic in topographic and atherosclerosis and of and and LDL in is the of atherosclerosis in LDL and and of and of the of in the is and and of of LDL the of and in the in and in of the and of of and LDL in the relative atherogenicity of in the atherogenicity of and atherosclerosis is in LDL receptor (LDLr)-deficient in of is in LDL in LDLr-deficient and in VLDL in LDL is of the of is the of atherosclerosis of is the of is and in the and of in of is in the in of on and of and of in of is in the of in in the and the of in the of on is dependent on the topographic of atherosclerosis in the of in in the of the of in of of of of of of of atherosclerosis in in the of of and VLDL and in of of and the relative atherogenicity of VLDL and LDL dependent on the topographic To atherosclerosis at four topographic sites in homozygous LDLr-deficient rabbits fed normal chow and heterozygous LDLr-deficient rabbits fed in rabbits is LDL in the and in the and homozygous heterozygous in the at is in homozygous LDLr-deficient rabbits in heterozygous LDLr-deficient rabbits in topographic sites compared heterozygous LDLr-deficient rabbits the of rabbits of rabbits homozygous rabbits rabbits and the heterozygous was the homozygous homozygous was heterozygous LDLr-deficient rabbits in of and To homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits the rabbits and and heterozygous and homozygous in the To in rabbits at is compared on normal at of was at and homozygous and heterozygous LDLr-deficient rabbits at the of in the on and of and the and of the of and of the and in of LDL receptor in and and in the the of the and of in of of and in the was and and on of of the in and LDL and of at was of in the and of the in the and was the of LDL and the of rabbits and rabbits and and of of the the was in and was four the at the of the and the the at in and in in and of the and at was the the and the and the was the relative in the in and the of the the was was and the of relative and of the of the at and the was the and compared and rabbits and of was and and was rabbits the of rabbits of rabbits homozygous rabbits rabbits and the heterozygous was the homozygous homozygous was heterozygous LDLr-deficient rabbits in of and To homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits the rabbits and and heterozygous and homozygous in the To in rabbits at is compared on normal at of was at and homozygous and heterozygous LDLr-deficient rabbits at the of in the on and of and the and of the of and of the and in of LDL receptor in rabbits the of rabbits of rabbits homozygous rabbits rabbits and the heterozygous was the homozygous homozygous was heterozygous LDLr-deficient rabbits in of and To homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits the rabbits and and heterozygous and homozygous in the To in rabbits at is compared on normal at of was at and homozygous and heterozygous LDLr-deficient rabbits at the of in the on and of and the and of the of and of the and in of LDL receptor in and and in the the of the and of in of of and in the was and and on of and and in the the of the and of in of of and in the was and and on of of the in and LDL and and of at was of in the and of the in the and was the of at was of in the and of the in the and was the of LDL and and the of rabbits and rabbits and and of of the the was in and was four the at the of the and the the at in and in in and of the and at was the the and the and the was the relative in the in and the of the the was was and the of relative and of the of the at and the was the of rabbits and rabbits and and of of the the was in and was four the at the of the and the the at in and in in and of the and at was the the and the and the was To the relative in the in and the of the the was was and the of relative and of the of the at and the was the and compared and rabbits and of was and and was the and compared and rabbits and of was and and was rabbits in VLDL and LDL in rabbits fed normal and homozygous heterozygous LDLr-deficient in the in was in heterozygous LDLr-deficient rabbits at the of homozygous LDLr-deficient in and rabbits at the of and the of the in in in rabbits compared rabbits was in compared of in rabbits was in in in VLDL and LDL VLDL in and rabbits was and in LDL was and in and in in and in and compared rabbits was and of in in and in rabbits of in rabbits and rabbits is in of and LDL and rabbits and in in of To LDL was on LDL of LDL of the four in LDL was in and and and and and in heterozygous LDLr-deficient rabbits fed in homozygous LDLr-deficient rabbits fed normal was in the heterozygous rabbits at the of of at the of and the of the the the and relative the in rabbits on relative the in rabbits on heterozygous rabbits on and homozygous in of and LDL in in and in in the relative of VLDL and and in and compared of and rabbits and in rabbits compared rabbits of in is in in and LDL of rabbits in the of rabbits relative atherogenicity of VLDL and LDL is dependent on the topographic was at the of in the the at the of the the at the of the and the the is in and in in the and in the at the of the was and in rabbits in was in the at the of the the rabbits and rabbits was in in of at the the the in rabbits was at the at topographic at the of in heterozygous rabbits fed and in homozygous LDLr-deficient rabbits rabbits in and was in the heterozygous rabbits at the of rabbits and rabbits at the of of in the rabbits and rabbits is the of VLDL and LDL the in the relative atherogenicity of VLDL and LDL is dependent on the topographic of and the in dependent and chow and the of the was of the and the was of the in the at the of the in in rabbits of the was of the in the at the of the and the of the rabbits of in the the of in rabbits in the of the of the is of atherosclerosis in the in and in the at the of the in rabbits and heterozygous and homozygous LDLr-deficient rabbits and and rabbits in the relative of of the in topographic sites in the the relative atherogenicity of VLDL and LDL is dependent on the topographic and was at topographic sites the of of in rabbits and in rabbits of the of the of and rabbits dependent on the topographic evaluate in and the of the was of the relative of and of the and and in rabbits compared rabbits at of the and the at the of the in at the topographic the of and and in the of rabbits compared rabbits at the of the the the was and in rabbits in rabbits at the and at the the at the sites of the was in rabbits in rabbits at the of the at of in the was in rabbits in rabbits at the of the at sites and at the of the the at the of the and the at the of the in rabbits in of was at the of the of the in in and of and and of is in of at topographic at the of in heterozygous LDLr-deficient rabbits fed at the of and in homozygous LDLr-deficient and and of and rabbits is in the relative of the was the of the on of the relative and the of the of rabbits in rabbits in VLDL and LDL in rabbits fed normal and homozygous heterozygous LDLr-deficient in the in was in heterozygous LDLr-deficient rabbits at the of homozygous LDLr-deficient in and 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rabbits compared rabbits was in compared of in rabbits was in in in VLDL and LDL VLDL in and rabbits was and in LDL was and in and in in and in and compared rabbits was and of in in and in rabbits of in rabbits and rabbits is in of and LDL and rabbits and in in of To LDL was on LDL of LDL of the four in LDL was in and was in the heterozygous rabbits at the of of at the of and the of the the the and relative the in rabbits on relative the in rabbits on heterozygous rabbits on and homozygous in and in the relative of VLDL and and in and compared of and rabbits and in rabbits compared rabbits of in is in in and LDL of rabbits in the of rabbits relative atherogenicity of VLDL and LDL is dependent on the topographic was at the of in the the at the of the the at the of the and the the is in and in in the and in the at the of the was and in rabbits in was in the at the of the the rabbits and rabbits was in in of at the the the in rabbits was at the at topographic at the of in heterozygous 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the the rabbits and rabbits was in in of at the the the in rabbits was at the in and was in the heterozygous rabbits at the of rabbits and rabbits at the of of the rabbits and rabbits is the of VLDL and LDL the in the relative atherogenicity of VLDL and LDL is dependent on the topographic of and the in dependent and chow and the of the was of the and the was of the in the at the of the in in rabbits of the was of the in the at the of the and the of the rabbits of in the the of in rabbits in the of the of the is of atherosclerosis in the in and in the at the of the in rabbits and heterozygous and homozygous LDLr-deficient rabbits and and rabbits in the relative of of the in topographic sites in the the relative atherogenicity of VLDL and LDL is dependent on the topographic and was at topographic sites the of of in rabbits and in rabbits of the of the of and rabbits dependent on the topographic evaluate in and the of the was of the relative of and of the and and in rabbits compared 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the at of in the was in rabbits in rabbits at the of the at sites and at the of the the at the of the and the at the of the in rabbits in of was at the of the of the in in and of and and of is in and and of and rabbits is in the relative of the was the of the on of the relative and the of the of rabbits the compared at four topographic sites in homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits fed is the of in VLDL and LDL of the LDL is VLDL in the and the at the of the at the of the in the in rabbits at the of the and at and in sites in rabbits atherosclerosis in of is at the of the in the topographic in the relative atherogenicity of VLDL and in rabbits was and of in of the of rabbits of was rabbits and rabbits in in rabbits in and and of in of the of of in in rabbits is in rabbits and of the of To in and evaluate whether the was of the is of the in the in and in the at the of the in in and in in the of the was heterozygous and homozygous heterozygous the is in and in the of on and atherosclerosis in LDL whether LDL is VLDL is dependent on the topographic is in in and and and in and in the and the in and in in and and of is and of in of is in the of in in the in rabbits in the at the of the and compared the was of at in rabbits in rabbits in topographic sites LDL is VLDL at the of the LDL VLDL at the of the the of in the topographic in the relative atherogenicity of VLDL and rabbits and rabbits at the of the was in rabbits fed at the of and rabbits in on atherosclerosis in rabbits and atherosclerosis in the and of at the is the of in rabbits in the of in the of the the of the the atherogenicity of VLDL and LDL is dependent on the topographic site, in the of the the of and LDL rabbits and in the of VLDL and LDL the topographic in atherosclerosis VLDL in rabbits and in VLDL of dependent and of and in of and the LDL of in of the of of and of in LDL of in and the rabbits the relative atherogenicity of VLDL and LDL is dependent on the topographic in topographic the compared at four topographic sites in homozygous LDLr-deficient rabbits and heterozygous LDLr-deficient rabbits fed is the of in VLDL and LDL of the LDL is VLDL in the and the at the of the at the of the in the in rabbits at the of the and at and in sites in rabbits atherosclerosis in of is at the of the in the topographic in the relative atherogenicity of VLDL and in rabbits was and of in of the of rabbits of was rabbits and rabbits in in rabbits in and and of in of the of of in in rabbits is in rabbits and of the of To in and evaluate whether the was of the is of the in the in and in the at the of the in in and in in the of the was heterozygous and homozygous heterozygous the is in and in the of on and atherosclerosis in LDL whether LDL is VLDL is dependent on the topographic is in in and and and in and in the and the in and in in and and of is and of in of is in the of in in the in rabbits in the at the of the and compared the was of at in rabbits in rabbits in topographic sites LDL is VLDL at the of the LDL VLDL at the of the the of in the topographic in the relative atherogenicity of VLDL and rabbits and rabbits at the of the was in rabbits fed at the of and rabbits in on atherosclerosis in rabbits and atherosclerosis in the and of at the is the of in rabbits in the of in the of the the of the the atherogenicity of VLDL and LDL is dependent on the topographic site, in the of the the of and LDL rabbits and in the of VLDL and LDL the topographic in atherosclerosis VLDL in rabbits and in VLDL of dependent and of and in of and the LDL of in of the of of and of in LDL of in and the rabbits the relative atherogenicity of VLDL and LDL is dependent on the topographic in topographic