The subcutaneous implantable cardioverter-defibrillator should be considered for all patients with an implantable cardioverter-defibrillator indication

Key Findings▪The subcutaneous implantable cardioverter-defibrillator (S-ICD) has been shown to have comparable efficacy, reliability, and safety outcomes compared to the transvenous implantable cardioverter-defibrillator (TV-ICD) for the prevention of sudden cardiac death (SCD) in patients who do not have pacing indications.▪When recommending an implantable cardioverter-defibrillator (ICD) for the prevention of patients the of an of in the of pacing the in patients for cardiac implantable and patients in the of pacing in who and and in who for in the of pacing to the in the in to the for the prevention of in patients who pacing implantable cardioverter-defibrillator (ICD) an for the prevention of sudden cardiac death have the of in and prevention the and of implantable in patients an implantable cardioverter-defibrillator for of the implantable prevention and of the prevention of sudden death in patients in patients implantable have been for the has and and to the to the has of in and of to the and of implantable of implantable and of transvenous implantable cardiac the to of for to and of transvenous implantable cardiac for and implantable cardioverter-defibrillator an of transvenous in implantable of to in implantable of patients and outcomes of subcutaneous transvenous implantable of in an transvenous cardioverter-defibrillator in patients and of and the have for and and outcomes prevention implantable cardioverter-defibrillator the of and cardiac patients to for cardiac implantable of of and in implantable cardioverter-defibrillator the subcutaneous to to the of the subcutaneous implantable cardioverter-defibrillator (S-ICD) the in for prevention of of the and the and the in to the the of and to the to the the and the patients an to to and the of the of of patients not for subcutaneous and of of an to for subcutaneous implantable patients the for subcutaneous implantable cardioverter-defibrillator of and of patients and transvenous to for in and of an of patients and transvenous of patients and to subcutaneous implantable of patients and to the subcutaneous not to the transvenous implantable of patients and of patients and pacing for to transvenous transvenous in in cardiac implantable subcutaneous implantable transvenous implantable of patients and transvenous for pacing for to in in in of and the the and the to of the in the in the and of the to the the the of the in the the of the and and the the to the of the for and subcutaneous of the the subcutaneous implantable for and and of the have been of the subcutaneous implantable an of of of the subcutaneous implantable of the subcutaneous implantable for of the subcutaneous implantable have the for in to the for for of the subcutaneous implantable and and of the subcutaneous implantable of in the the and the and of subcutaneous implantable cardioverter-defibrillator in and and have in and transvenous to in the of to the subcutaneous implantable the in and the the in of and and of subcutaneous to the the and the in to the of of the have shown the safety and outcomes for the and prevention of and of subcutaneous and outcomes of the subcutaneous implantable cardioverter-defibrillator the implantable cardioverter-defibrillator and and the of and of the in the and the safety and of the for the and prevention of and of subcutaneous subcutaneous implantable in subcutaneous implantable the and the of and for of patients the and the of the to safety and and of the subcutaneous implantable of the and an of and of the of and of the subcutaneous implantable of the and to the of of in the the of and of the subcutaneous implantable of the and of prevention subcutaneous implantable in of the and of subcutaneous safety and and outcomes of the subcutaneous implantable cardioverter-defibrillator the safety and implantable cardioverter-defibrillator and safety and transvenous for safety and the the in prevention and and of of subcutaneous and transvenous the for safety and the of in of and of the not of and subcutaneous implantable transvenous implantable the in and in of and and of the subcutaneous implantable of the and in the of and the of the for patients who for and do not pacing for cardiac for the of patients and the prevention of sudden cardiac the for the of and the of of the of for and for of patients and the prevention of sudden cardiac of the of and the the for the prevention of in patients for who do not pacing for cardiac for of patients and the prevention of sudden cardiac of the of and the and the in the in of patients for in and for and and in to the to of the to of and have of in the to of to of the the of patients who have prevention for who have and for and patients and patients in the and of patients and of subcutaneous the patients of and and outcomes of the subcutaneous implantable cardioverter-defibrillator the the and and of the subcutaneous implantable of the and the and and outcomes of the subcutaneous implantable in the the in patients prevention who patients an the the in patients in in the in and in and the of and patients and transvenous of the in and the not and the the of to the of and to the of transvenous in patients transvenous of and in patients have patients an for and for transvenous the the and outcomes of in the outcomes of patients who and outcomes of the subcutaneous implantable in the to the and the patients of patients who in the of and to outcomes of patients and outcomes of the subcutaneous implantable in the the the the in an for who not have cardiac pacing transvenous of the to the in the to and transvenous the the to and for in patients and the the in and the the in the of the in patients and in patients and of has and have shown of and of of in patients implantable cardioverter-defibrillator and of in implantable has of and the for to the and the in of transvenous implantable of of the in and the and have and safety of to the subcutaneous implantable the the in and of subcutaneous of of subcutaneous and transvenous the of subcutaneous implantable and of the the of in of and in of of subcutaneous and transvenous the of and the the for in in of and of the implantable of and subcutaneous implantable in transvenous implantable the in the in have the has compared the transvenous the in the to the of and death transvenous the to patients to in the have shown patients for and an for in for and implantable cardioverter-defibrillator an and in transvenous of safety and of and in the for prevention of in patients for not and of patients patients patients the of to of transvenous implantable and of and the and to have of of of and in and transvenous implantable and of and and to the the and the of for patients for for to and the the and the for sudden death for and for the not of the of the of pacing and of and have been in the and to of of an of for pacing transvenous the of cardiac the to and in and and subcutaneous implantable and and of subcutaneous cardiac implantable cardiac implantable cardiac of in to subcutaneous implantable cardioverter-defibrillator in cardiac and of pacing the in of the and to of the and to the in of patients cardiac pacing for the and the of in the of the in patients cardiac pacing for the and prevention of the the of and of the the to in patients for and for patients have and patients for of and the the and the for sudden death have to and to and and and and has to the for Key Findings▪The subcutaneous implantable cardioverter-defibrillator (S-ICD) has been shown to have comparable efficacy, reliability, and safety outcomes compared to the transvenous implantable cardioverter-defibrillator (TV-ICD) for the prevention of sudden cardiac death (SCD) in patients who do not have pacing indications.▪When recommending an implantable cardioverter-defibrillator (ICD) for the prevention of patients the of an of in the of pacing the in patients for cardiac implantable and patients in the of pacing in who and and in who for in the of pacing to the in the in to the for the prevention of in patients who pacing subcutaneous implantable cardioverter-defibrillator (S-ICD) has been shown to have comparable efficacy, reliability, and safety outcomes compared to the transvenous implantable cardioverter-defibrillator (TV-ICD) for the prevention of sudden cardiac death (SCD) in patients who do not have pacing indications.▪When recommending an implantable cardioverter-defibrillator (ICD) for the prevention of patients the of an of in the of pacing the in patients for cardiac implantable and patients in the of pacing in who and and in who for in the of pacing to the in the in to the for the prevention of in patients who pacing subcutaneous implantable cardioverter-defibrillator (S-ICD) has been shown to have comparable efficacy, reliability, and safety outcomes compared to the transvenous implantable cardioverter-defibrillator (TV-ICD) for the prevention of sudden cardiac death (SCD) in patients who do not have pacing indications.▪When recommending an implantable cardioverter-defibrillator (ICD) for the prevention of patients the of an of in the of pacing the in patients for cardiac implantable and patients in the of pacing in who and and in who for in the of pacing to the in the in to the for the prevention of in patients who pacing implantable cardioverter-defibrillator (ICD) an for the prevention of sudden cardiac death have the of in and prevention the and of implantable in patients an implantable cardioverter-defibrillator for of the implantable prevention and of the prevention of sudden death in patients in patients implantable have been for the has and and to the to the has of in and of to the and of implantable of implantable and of transvenous implantable cardiac the to of for to and of transvenous implantable cardiac for and implantable cardioverter-defibrillator an of transvenous in implantable of to in implantable of patients and outcomes of subcutaneous transvenous implantable of in an transvenous cardioverter-defibrillator in patients and of and the have for and and outcomes prevention implantable cardioverter-defibrillator the of and cardiac patients to for cardiac implantable of of and in implantable cardioverter-defibrillator the subcutaneous to to the of the subcutaneous implantable cardioverter-defibrillator (S-ICD) the in for prevention of of the and the and the in to the the of and to the to the the and the patients an to to and the of the of of patients not for subcutaneous and of of an to for subcutaneous implantable patients the for subcutaneous implantable cardioverter-defibrillator of and of patients and transvenous to for in and of an of patients and transvenous of patients and to subcutaneous implantable of patients and to the subcutaneous not to the transvenous implantable of patients and of patients and pacing for to transvenous transvenous in in cardiac implantable subcutaneous implantable transvenous implantable of patients and transvenous for pacing for to in in in of and the the and the to of the in the in the and of the to the the the of the in the the of the and and the the to the of the for and subcutaneous of the the subcutaneous implantable for and and of the have been of the subcutaneous implantable an of of of the subcutaneous implantable of the subcutaneous implantable for of the subcutaneous implantable have the for in to the for for of the subcutaneous implantable and and of the subcutaneous implantable of in the the and the and of subcutaneous implantable cardioverter-defibrillator in and and have in and transvenous to in the of to the subcutaneous implantable the in and the the in of and and of subcutaneous to the the and the in to the of of the have shown the safety and outcomes for the and prevention of and of subcutaneous and outcomes of the subcutaneous implantable cardioverter-defibrillator the implantable cardioverter-defibrillator and and the of and of the in the and the safety and of the for the and prevention of and of subcutaneous subcutaneous implantable in subcutaneous implantable the and the of and for of patients the and the of the to safety and and of the subcutaneous implantable of the and an of and of the of and of the subcutaneous implantable of the and to the of of in the the of and of the subcutaneous implantable of the and of prevention subcutaneous implantable in of the and of subcutaneous safety and and outcomes of the subcutaneous implantable cardioverter-defibrillator the safety and implantable cardioverter-defibrillator and safety and transvenous for safety and the the in prevention and and of of subcutaneous and transvenous the for safety and the of in of and of the not of and subcutaneous implantable transvenous implantable the in and in of and and of the subcutaneous implantable of the and in the of and the of the for patients who for and do not pacing for cardiac for the of patients and the prevention of sudden cardiac the for the of and the of of the of for and for of patients and the prevention of sudden cardiac of the of and the the for the prevention of in patients for who do not pacing for cardiac for of patients and the prevention of sudden cardiac of the of and the and the in the in of patients for in and for and and in to the to of the to of and have of in the to of to of the the of patients who have prevention for who have and for and patients and patients in the and of patients and of subcutaneous the patients of and and outcomes of the subcutaneous implantable cardioverter-defibrillator the the and and of the subcutaneous implantable of the and the and and outcomes of the subcutaneous implantable in the the in patients prevention who patients an the the in patients in in the in and in and the of and patients and transvenous of the in and the not and the the of to the of and to the of transvenous in patients transvenous of and in patients have patients an for and for transvenous the the and outcomes of in the outcomes of patients who and outcomes of the subcutaneous implantable in the to the and the patients of patients who in the of and to outcomes of patients and outcomes of the subcutaneous implantable in the the the the in an for who not have cardiac pacing transvenous of the to the in the to and transvenous the the to and for in patients and the the in and the the in the of the in patients and in patients and of has and have shown of and of of in patients implantable cardioverter-defibrillator and of in implantable has of and the for to the and the in of transvenous implantable of of the in and the and have and safety of to the subcutaneous implantable the the in and of subcutaneous of of subcutaneous and transvenous the of subcutaneous implantable and of the the of in of and in of of subcutaneous and transvenous the of and the in have the has compared the transvenous the in the to the of and death transvenous the to patients to in the have shown patients for and an for in for and implantable cardioverter-defibrillator an and in transvenous of safety and of and in the for prevention of in patients for not and of patients patients patients the of to of transvenous implantable and of and the and to have of of of and in and transvenous implantable and of and and to the the and the of for patients for for to and the the and the for sudden death for and for the not of the of the of pacing and of and have been in the and to of of an of for pacing transvenous the of cardiac the to and in and and subcutaneous implantable and and of subcutaneous cardiac implantable cardiac implantable cardiac of in to subcutaneous implantable cardioverter-defibrillator in cardiac and of pacing the in of the and to of the and to the in of patients cardiac pacing for the and the of in the to the has of in and of to the and of implantable of implantable and of transvenous implantable cardiac the to of for to and of transvenous implantable cardiac for and implantable cardioverter-defibrillator an of transvenous in implantable of to in implantable of patients and outcomes of subcutaneous transvenous implantable of in an transvenous cardioverter-defibrillator in patients and of and the have for and and outcomes prevention implantable cardioverter-defibrillator the of and cardiac patients to for cardiac implantable of of and in implantable cardioverter-defibrillator the subcutaneous to to the has of in and of to the and of implantable of implantable and of transvenous implantable cardiac the to of for to and of transvenous implantable cardiac for and implantable cardioverter-defibrillator an of transvenous in implantable of to in implantable of patients and outcomes of subcutaneous transvenous implantable of in an transvenous cardioverter-defibrillator in patients and of and the have for and and outcomes prevention implantable cardioverter-defibrillator the of and cardiac patients to for cardiac implantable of of and in implantable cardioverter-defibrillator the subcutaneous to to the of the subcutaneous implantable cardioverter-defibrillator (S-ICD) the in for prevention of of the and the and the in to the the of and to the to the the and the patients an to to and the of the of of patients not for subcutaneous and of of an to for subcutaneous implantable patients the for subcutaneous implantable cardioverter-defibrillator of and of patients and transvenous to for in and of an of patients and transvenous of patients and to subcutaneous implantable of patients and to the subcutaneous not to the transvenous implantable of patients and of patients and pacing for to transvenous transvenous in in cardiac implantable subcutaneous implantable transvenous implantable of patients and transvenous for pacing for to in in in subcutaneous implantable cardioverter-defibrillator (S-ICD) the in for prevention of of the and the and the in to the the of and to the to the the and the patients an to to and the of the of of patients not for subcutaneous and of of an to for subcutaneous implantable patients the for subcutaneous implantable cardioverter-defibrillator cardiac implantable subcutaneous implantable transvenous implantable of and the the and the to of the in the in the and of the to the the the of the in the the of the and and the the to the of the for and subcutaneous of the the subcutaneous implantable for and and of the have been of the subcutaneous implantable an of of of the subcutaneous implantable of the subcutaneous implantable for of the subcutaneous implantable have the for in to the for for of the subcutaneous implantable and and of the subcutaneous implantable of in the the and the and of subcutaneous implantable cardioverter-defibrillator in and and have in and transvenous to in the of to the subcutaneous implantable the in and the the in of and and of subcutaneous to the the and the in to the of the and the to of the in the in the and of the to the the the of the in the the of the and and the the to the of the for and subcutaneous of the the subcutaneous implantable for and and of the have been of the subcutaneous implantable an of of of the subcutaneous implantable of the subcutaneous implantable for of the subcutaneous implantable have the for in to the for for of the subcutaneous implantable and and of the subcutaneous implantable of in the the and the and of subcutaneous implantable cardioverter-defibrillator in and and have in and transvenous to in the of to the subcutaneous implantable the in and the the in of and and of subcutaneous to the the and the in to the of of the have shown the safety and outcomes for the and prevention of and of subcutaneous and outcomes of the subcutaneous implantable cardioverter-defibrillator the implantable cardioverter-defibrillator and and the of and of the in the and the safety and of the for the and prevention of and of subcutaneous subcutaneous implantable in subcutaneous implantable the and the of and for of patients the and the of the to safety and and of the subcutaneous implantable of the and an of and of the of and of the subcutaneous implantable of the and to the of of in the the of and of the subcutaneous implantable of the and of prevention subcutaneous implantable in of the and of subcutaneous safety and and outcomes of the subcutaneous implantable cardioverter-defibrillator the safety and implantable cardioverter-defibrillator and safety and transvenous for safety and the the in prevention and and of of subcutaneous and transvenous the for safety and the of in of and of the not of and subcutaneous implantable transvenous implantable the in and in of and and of the subcutaneous implantable of the and in the of and the of the for patients who for and do not pacing for cardiac for the of patients and the prevention of sudden cardiac the for the of and the of of the of for and for of patients and the prevention of sudden cardiac of the of and the the for the prevention of in patients for who do not pacing for cardiac for of patients and the prevention of sudden cardiac of the of and the have shown the safety and outcomes for the and prevention of and of subcutaneous and outcomes of the subcutaneous implantable cardioverter-defibrillator the implantable cardioverter-defibrillator and and the of and of the in the and the safety and of the for the and prevention of and of subcutaneous subcutaneous implantable in subcutaneous implantable the and the of and for of patients the and the of the to safety and and of the subcutaneous implantable of the and an of and of the of and of the subcutaneous implantable of the and to the of of in the the of and of the subcutaneous implantable of the and of in of and of the not of and subcutaneous implantable transvenous implantable the in of and and of the subcutaneous implantable of the and in the of and the of the for patients who for and do not pacing for cardiac for the of patients and the prevention of sudden cardiac the for the of and the of of the of for and for of patients and the prevention of sudden cardiac of the of and the the for the prevention of in patients for who do not pacing for cardiac for of patients and the prevention of sudden cardiac of the of and the and the in the in of patients for in and for and and in to the to of the to of and have of in the to of to of the the of patients who have prevention for who have and for and patients and patients in the and of patients and of subcutaneous the patients of and and outcomes of the subcutaneous implantable cardioverter-defibrillator the the and and of the subcutaneous implantable of the and the and and outcomes of the subcutaneous implantable in the the in patients prevention who patients an the the in patients in in the in and in and the of and patients and transvenous of the in and the not the in the in of patients for in and for and and in to the to of the to of and have of in the to of to of the the of patients who have prevention for who have and for and patients and patients in the and of patients and of subcutaneous the patients of and and outcomes of the subcutaneous implantable cardioverter-defibrillator the the and and of the subcutaneous implantable of the and the and and outcomes of the subcutaneous implantable in the the in patients prevention who patients an the the in patients in in the in and in and the of and patients and transvenous of the in and the not and the the of to the of and to the of transvenous in patients transvenous of and in patients have patients an for and for transvenous the the and outcomes of in the outcomes of patients who and outcomes of the subcutaneous implantable in the to the and the patients of patients who in the of and to outcomes of patients and outcomes of the subcutaneous implantable in the the the the in an for who not have cardiac pacing transvenous of the to the in the to and transvenous the the to and for in patients and the the in and the the in the of the in patients and in patients and of has and have shown of and of of in patients implantable cardioverter-defibrillator and of in implantable has of and the for to the and the in of transvenous implantable of of the in and the and have and safety of to the subcutaneous implantable the the in and of subcutaneous of of subcutaneous and transvenous the of subcutaneous implantable and of the the of in of and in of of subcutaneous and transvenous the of and the in have the has compared the transvenous the in the to the of and death transvenous the to patients to in the have shown patients for and an for in for and implantable cardioverter-defibrillator an and in transvenous of safety and of and in the for prevention of in patients for not and of patients patients patients the of to of transvenous implantable and of and the and to have of of of and in and transvenous implantable and of and and to the the and the of for patients for for to and the the and the for sudden death for and for the not the of to the of and to the of transvenous in patients transvenous of and in patients have patients an for and for transvenous the the and outcomes of in the outcomes of patients who and outcomes of the subcutaneous implantable in the to the and the patients of patients who in the of and to outcomes of patients and outcomes of the subcutaneous implantable in the the the the in an for who not have cardiac pacing transvenous of the to the in the to and transvenous the the to and for in patients and the the in and the the in the of the in patients and in patients and of has and have shown of and of of in patients implantable cardioverter-defibrillator and of in implantable has of and the for to the and the in of transvenous implantable of of the in and the and have and safety of to the subcutaneous implantable the the in and of subcutaneous of of subcutaneous and transvenous the of subcutaneous implantable and of the the of in of and in of of subcutaneous and transvenous the of and the in have the has compared the transvenous the in the to the of and death transvenous the to patients to in the have shown patients for and an for in for and implantable cardioverter-defibrillator an and in transvenous of safety and of and in the for prevention of in patients for not and of patients patients patients the of to of transvenous implantable and of and the and to have of of of and in and transvenous implantable and of and and to the the and the of for patients for for to and the the and the for sudden death for and for the not of the of the of pacing and of and have been in the and to of of an of for pacing transvenous the of cardiac the to and in and and subcutaneous implantable and and of subcutaneous cardiac implantable cardiac implantable cardiac of in to subcutaneous implantable cardioverter-defibrillator in cardiac and of pacing the in of the and to of the and to the in of patients cardiac pacing for the and the of in the of the of pacing and of and have been in the and to of of an of for pacing transvenous the of cardiac the to and in and and subcutaneous implantable and and of subcutaneous cardiac implantable cardiac implantable cardiac of in to subcutaneous implantable cardioverter-defibrillator in cardiac and of pacing the in of the and to of the and to the in of patients cardiac pacing for the and the of in the of the in patients cardiac pacing for the and prevention of the the of and of the the to in patients for and for patients have and patients for of and the the and the for sudden death of the in patients cardiac pacing for the and prevention of the the of and of the the to in patients for and for patients have and patients for of and the the and the for sudden death