The goal of this study was to evaluate to what extent pregnancy influences headache recurrence in women with a diagnosis of migraine at, or before, their first prenatal visit. Data from the large, prospective Collaborative Perinatal Project of 55,000 pregnancies were reviewed. Less than 2% of women in the sample of first study pregnancies were considered to have migraine at their initial prenatal visit (n = 508). Of the 484 women with a complete data set, 17% experienced complete cessation of headache throughout pregnancy and another 62% experienced two or fewer headaches in the third trimester. These observations lead to the conclusion that many migraineurs (79% in this sample) experience improvement in headache recurrence during pregnancy. Only 21% experienced no improvement at all. No demographic or obstetrical factor was associated with headache improvement.
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Chen et al. (1994) studied this question.