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The preservation of the antioxidant capacity of ascorbic acid by 2-hydroxypropyl-β-cyclodextrins has been studied. For this, a model system consisting of ascorbic acid, H 2 O 2, a phenolic compound, 2,2,5,7,8-pentamethylchroman-6-ol (PMC), and commercial soybean lipoxygenase was used. In this system, ascorbic acid was oxidized by PMC radicals generated by the hydroperoxidative activity of lipoxygenase, giving rise to a biphasic curve, in which the inflection point represents the time at which all the ascorbic acid has been consumed ( t ip ). This t ip depends on the enzyme, ascorbic acid, and PMC concentration. When 2-hydroxypropyl-β-cyclodextrins were included in the system, the t ip increased, indicating that these cyclodextrins were acting as secondary antioxidants, so preserving the antioxidant capacity of the system. A mathematical model to explain the effect of cyclodextrins on ascorbic acid oxidation in this experimental system is described, giving a constant, K c, which represents the preservation capacity of a particular antioxidant system produced by cyclodextrins.
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Núñez‐Delicado et al. (1997) studied this question.
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