Plasma serotonin concentrations are elevated in type 1 diabetic patients compared to healthy controls, irrespective of vascular disease status.
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Elevated serotonin in type 1 diabetes is hypothesis-generating; leaves open causal role and clinical utility pending prospective validation.
Platelet and plasma vasoactive amine concentrations were measured in healthy controls and in type 1 (insulin-dependent) diabetic patients with or without vascular disease. Platelet concentrations of serotonin and noradrenaline were similar in all groups and were unrelated to age or gender, or to duration of diabetes, blood pressure, glycaemia or renal function in the diabetic subjects. Plasma concentrations of serotonin in the diabetic groups were comparable (118 +/- 16 (mean +/- SEM) and 127 +/- 21 pmol/mL), and were significantly higher in comparison to the healthy controls (66 +/- 12 pmol/mL, P = 0.002).
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Winocour et al. (1990) studied this question.
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