Key result
Type 1 diabetes mellitus is linked to increased platelet F-actin, spontaneous aggregation, and PAF-hydrolase.
Why the study?
Are platelet reactivity parameters, including F-actin values, altered in patients with type I diabetes mellitus compared to healthy controls?
Population
20 patients with type I diabetes mellitus and an age- and sex-matched control group
Design
Case-control
Authors
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May support platelet hyperreactivity in type 1 diabetes; hypothesis-generating and should not yet change practice.
Case-Control
Are platelet reactivity parameters, including F-actin values, altered in patients with type I diabetes mellitus compared to healthy controls?
Patients with type I diabetes mellitus exhibit increased platelet hyperreactivity, as indicated by elevated F-actin values, spontaneous aggregation, and PAF-hydrolase.
Spangenberg et al. (2009) conducted a case-control in Type I Diabetes Mellitus. Type I Diabetes Mellitus vs. Age- and sex-matched control group was evaluated on F-actin values, spontaneous aggregation, and PAF-hydrolase. Type I diabetes mellitus was associated with significantly increased platelet F-actin values, spontaneous aggregation, and PAF-hydrolase compared to age- and sex-matched controls.
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