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March 1, 2000Planta Medica

S-Allylcysteine Ameliorates Doxorubicin Toxicity in the Heart and Liver in Mice

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Why the study?

Does S-Allylcysteine reduce mortality and cardiotoxicity in mice treated with doxorubicin?

Population

Mice with severe doxorubicin toxicity induced by a single intraperitoneal injection (15 mg/kg body weight)

Comparison

S-Allylcysteine 30 mg/kg injected… vs Doxorubicin only (no SAC treatment)

Design

Preclinical

Follow-up

6 days after doxorubicin administration

Authors

MMMohammed Gulam MostafaAssiut UniversitySOS. Tsuyoshi OhnishiKanazawa UniversityKMKoreaki MoriTohoku University

Discussion

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Member takes

Overview

Hypothesis-generating for S-allylcysteine cardioprotection in mice; leaves open translation to human chemotherapy.

Structured PICO

Does S-Allylcysteine reduce mortality and cardiotoxicity in mice treated with doxorubicin?

P
Population
Mice with severe doxorubicin toxicity induced by a single intraperitoneal injection (15 mg/kg body weight)
I
Intervention
S-Allylcysteine (SAC) 30 mg/kg injected intraperitoneally daily for 5 days, starting two days prior to doxorubicin administration
C
Comparator
Doxorubicin only (no SAC treatment)
O
Outcome
Mortality rate, body weight loss, serum creatine phosphokinase (CPK) levels, and histopathological analysis of the heart and liver at 6 days after doxorubicin administrationhard clinical

S-Allylcysteine attenuates doxorubicin-induced mortality, cardiotoxicity, and hepatotoxicity in a mouse model, suggesting potential as a protective agent during cancer chemotherapy.

Cite This Study

Mostafa et al. (2000) studied this question.

synapsesocial.com/papers/6a7d678f2d005ba2c41cd598https://doi.org/10.1055/s-2000-11124
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.1981 · 245 citations
  2. 2The Role of N-Acetyl Cysteine in Ameliorating Doxorubicin Induced Cardiotoxicity in Rats2022 · 4 citations
  3. 3Effect of the Anticancer Drug Doxorubicin (Adriamycin) on Antioxidant Studies and Ultrastructural Investigation in the Liver, Kidney, and Heart Tissues of Male Rats2023 · 2 citations
  4. 4Angiotensin receptor-neprilysin inhibition by sacubitril/valsartan attenuates doxorubicin-induced cardiotoxicity in a pretreatment mice model by interfering with oxidative stress, inflammation, and Caspase 3 apoptotic pathway2021 · 26 citations
  5. 5Doxorubicin Toxicity can be Ameliorated during Antioxidant L‐Carnitine Supplementation2010 · 79 citations